1H-吡咯并[2,3-c]吡啶-2-羧酸乙酯合成路线 （共 6 条）
反应条件
iron; ammonium chloride in tetrahydrofuran; ethanol; water 1 h; Heating / reflux;
参考文献
WO2004/104001 A2, ;
Page 33-34 ;
WO 2004/104001 A2
反应条件
1: 3-(tert-butyloxycarbonylamino)-4-methyl-pyridine With tert.-butyl lithium in tetrahydrofuran; pentane T=-40°C; 1 h; Inert atmosphere; 2: oxalic acid diethyl ester in tetrahydrofuran; pentane T=-40 - 20°C; 21.25 h; Inert atmosphere; 3: With hydrogenchloride in tetrahydrofuran; water; pentane 2 h; HeatingReflux;
参考文献
Dyke, Hazel Joan; Price, Stephen; Williams, Karen
Patent: US2010/216768 A1, 2010 ;
Location in patent: Page/Page column 16-17 ;
反应条件
1: With pyridine; ethyl orthosilicate; pyridinium p-toluenesulfonate T=20°C; 24 h; 2: With tetrakis(triphenylphosphine) palladium(0); N,N-dicyclohexylmethylamine T=160°C; 0.333333 h; Microwave irradiation;
参考文献
European Journal of Medicinal Chemistry, , vol. 54, p. 660 - 668
反应条件
1: pyridine; PPTS; Si(OEt)4 / 48 h / 20 °C 2: 272 mg / Cy2NH; pyridine / Pd(PPh3)4 / 0.67 h / 160 °C / microwave irradiation View Scheme
参考文献
Synthesis, , # 15 art. no. M01205SS, p. 2571 - 2577
反应条件
1: pyridine; PPTS; Si(OEt)4 / 48 h / 20 °C 2: 272 mg / Cy2NH; pyridine / Pd(PPh3)4 / 0.67 h / 160 °C / microwave irradiation View Scheme
参考文献
Synthesis, , # 15 art. no. M01205SS, p. 2571 - 2577
反应条件
sodium hydroxide; water in ethanol 1.5 h; Heating / reflux;
参考文献
Engelhardt, Harald; De Esch, Iwan J.P.; Kuhn, Daniel; Smits, Rogier A.; Zuiderveld, Obbe P.; Dobler, Julia; Mayer, Moriz; Lips, Sebastian; Arnhof, Heribert; Scharn, Dirk; Haaksma, Eric E.J.; Leurs, Rob
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 660 - 668
