1: N-bromoacetamide, AcOH / 3 h / Ambient temperature 2: 79 percent / MeONa / tetrahydrofuran / 4 h / Ambient temperature 3: N-bromosuccinimide, azoisobutyronitrile / CCl4 / 0.67 h / 60 - 70 °C 4: 62 percent / MeONa / tetrahydrofuran / 1) 0 deg C, 1 h, 2) rt, 3 h 5: trifluoroacetic acid / CDCl3 View Scheme

1: N-bromoacetamide, AcOH / 3 h / Ambient temperature 2: 79 percent / MeONa / tetrahydrofuran / 4 h / Ambient temperature 3: N-bromosuccinimide, azoisobutyronitrile / CCl4 / 0.67 h / 60 - 70 °C 4: 62 percent / MeONa / tetrahydrofuran / 1) 0 deg C, 1 h, 2) rt, 3 h 5: 27 percent / KOH / H2O; 2-methyl-propan-2-ol / 168 h / Ambient temperature View Scheme