6,8-二氟-4-羟基喹啉合成路线 （共 4 条）
反应条件
in diphenylether T=200°C; 0.333333 h; Heating / reflux;
参考文献
WO2008/124083 A2, ;
Page/Page column 54-55 ;
WO 2008/124083 A2
反应条件
1: 2,2-Dimethyl-[1,3]dioxane-4,6-dione With orthoformic acid triethyl ester T=145°C; 2: 4-fluoro-2-fluoroaniline T=50 - 145°C; 3: in diphenylether T=250°C;
参考文献
Journal of Organic Chemistry, , vol. 72, # 6 p. 2232 - 2235
反应条件
trichlorophosphate 3 h; Heating;
参考文献
AMGEN INC.
Patent: WO2008/124083 A2, 2008 ;
Location in patent: Page/Page column 55 ;
WO 2008/124083 A2
反应条件
phosphorus tribromide in N,N-dimethyl-formamide
T=20°C; 0.5 h;
参考文献
Margolis, Brandon J.; Long, Kimberly A.; Laird, Dana L. T.; Ruble, J. Craig; Pulley, Shon R.
Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 2232 - 2235
