(S)-2-羟基-3-甲基丁酸甲酯合成路线 （共 22 条）
反应条件
1: 2,6-lutidine / CH2Cl2 / 0.17 h 2: 1.) NaH / 1.) DMF, 0 deg C, 3 h, 2.) DMF, CH2Cl2, 0 deg C, 3 h 3: TFA / toluene / 5 h / Heating View Scheme
参考文献
Cregge, Robert J.; Durham, Sherrie L.; Farr, Robert A.; Gallion, Steven L.; Hare, C. Michelle; Hoffman, Robert V.; Janusz, Michael J.; Kim, Hwa-Ok; Koehl, Jack R.; Mehdi, Shujaath; Metz, William A.; Peet, Norton P.; Pelton, John T.; Schreuder, Herman A.; Sunder, Shyam; Tardif, Chantal
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2461 - 2480
反应条件
1: 93 percent / p-toluenesulfonic acid / diethyl ether
2: 88 percent / LiAlH4 / diethyl ether
3: pyridine / 4 h / 0 - 5 °C
4: p-toluenesulfonic acid / methanol / Ambient temperature
5: NaOMe / diethyl ether; methanol / 6 h / 0 °C
View Scheme
参考文献
Anand, Ramesh C.; Selvapalam, N.
Journal of Chemical Research, Miniprint, 1998 , # 1 p. 126 - 142
