5-苄氧基吲哚-3-乙腈合成路线 （共 13 条）
反应条件
methyl-magnesium iodide; diethyl ether Erwaermen des Reaktionsgemisches mit Chloracetonitril;
反应条件
in tetrahydrofuran; water Substitution; MeI adding to a pre-cooled indole (5 deg C) in THF; stirring overnight; aq. KCN adding; stirring at reflux under Ar;
参考文献
Perez-Alvarez, Victor; Morales-Rios, Martha S.; Hong, Enrique; Joseph-Nathan, Pedro
Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 3 p. 246 - 252
反应条件
sodium tetrahydroborate in methanol; formamide
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 9 p. 2571 - 2574
反应条件
methyl iodide Erwaermen des erhaltenen Methojodids mit NaCN in H2O;
参考文献
Helvetica Chimica Acta, , vol. 38, p. 1452,1469
反应条件
1: copper-powder; quinaldine / 245 - 250 °C 2: acetic acid; ethanol 3: CH3I / Erwaermen des erhaltenen Methojodids mit NaCN in H2O View Scheme
参考文献
Helvetica Chimica Acta, , vol. 38, p. 1452,1469
反应条件
1: Na2S2O4; aqueous NaOH 2: copper-powder; quinaldine / 245 - 250 °C 3: acetic acid; ethanol 4: CH3I / Erwaermen des erhaltenen Methojodids mit NaCN in H2O View Scheme
参考文献
Helvetica Chimica Acta, , vol. 38, p. 1452,1469
反应条件
1: LiAlH4; diethyl ether 2: palladium/charcoal; ethanol / Hydrogenation View Scheme
参考文献
Speeter et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 5514
参考文献
Morales-Rios, Martha S.; Santos-Sanchez, Norma F.; Suarez-Castillo, Oscar R.; Joseph-Nathan, Pedro
Journal of Organic Chemistry, 2003 , vol. 68, # 2 p. 305 - 311
反应条件
1: With lithium aluminium tetrahydride in diethyl ether 24 h; Reflux; 2: With water in diethyl ether Cooling;
参考文献
Hadjaz, Fariza; Besret, Soizic; Martin-Nizard, Francoise; Yous, Said; Dilly, Sebastien; Lebegue, Nicolas; Chavatte, Philippe; Duriez, Patrick; Berthelot, Pascal; Carato, Pascal
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2575 - 2585
反应条件
palladium 10 on activated carbon; hydrogen in tetrahydrofuran T=50°C; P=3000.3 Torr; 12 h; Inert atmosphere;
参考文献
Markl, Christian; Clafshenkel, William P.; Attia, Mohamed I.; Sethi, Shalini; Witt-Enderby, Paula A.; Zlotos, Darius P.
Archiv der Pharmazie, 2011 , vol. 344, # 10 p. 666 - 674
