2,4-二甲基吡咯-3,5-二羧酸二乙酯合成路线 （共 64 条）
反应条件
1,4-dioxane; Cr2Cu2O5
T=220 - 225°C; unter Druck;
参考文献
Signaigo; Adkins
Journal of the American Chemical Society, 1936 , vol. 58, p. 709,713,715
反应条件
ammonium cerium(IV) nitrate in tetrahydrofuran; water; acetic acid
1 h; Ambient temperature;
参考文献
Thyrann, Thomas; Lightner, David A.
Tetrahedron Letters, 1995 , vol. 36, # 25 p. 4345 - 4348
反应条件
sulfuryl dichloride; bromine; acetic acid
T=10 - 20°C;
参考文献
Nikitin, Edward B.; Dey, Sanjeev K.; Lightner, David A.
Monatshefte fur Chemie, 2009 , vol. 140, # 1 p. 97 - 110
反应条件
hydrazine hydrate
T=130°C;
参考文献
Fischer et al.
Justus Liebigs Annalen der Chemie, 1930 , vol. 481, p. 159,191
Full Text Show Details
Fischer; Waibel
Justus Liebigs Annalen der Chemie, 1934 , vol. 512, p. 195,209
反应条件
1: 67 percent / sulphuryl chloride / acetic acid / 0.5 h / 50 °C
2: 64 percent / 6percent aq. KOH / H2O / 2 h / Heating
View Scheme
参考文献
Brittain, Judith M.; Jones, R. Alan; Jones, Richard O.; King, Trevor J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 2656 - 2661
反应条件
1: glacial acetic acid; bromine / 38 - 45 °C
2: und anschliessend mit 2.4-Dimethyl-pyrrol-carbonsaeure-(3)-aethylester in Gegenwart von konz.Salzsaeure
View Scheme
参考文献
Corwin et al.
Journal of the American Chemical Society, 1942 , vol. 64, p. 1267,1271
反应条件
1: bromine; SO2Cl2; acetic acid / Reagens 4: Acetanhydrid; anschliessend Behandeln mit H2O
2: acetic acid; bromine
View Scheme
参考文献
Corwin et al.
Journal of the American Chemical Society, 1942 , vol. 64, p. 1267,1271
反应条件
in N,N-dimethyl-formamide
T=110°C; 4 h; Inert atmosphere;
参考文献
Sureshbabu, Radhakrishnan; Balamurugan, Ramalingam; Mohanakrishnan, Arasambattu K.
Tetrahedron, 2009 , vol. 65, # 18 p. 3582 - 3591
反应条件
in N-methyl-acetamide; water; mineral oil
参考文献
Ciba-Geigy Corporation
Patent: US4256759 A1, 1981 ;
反应条件
bromine in acetic acid
T=40 - 43°C; 0.5 h;
参考文献
Byun; Lightner
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 7 p. 1683 - 1692
