potassium tert-butylate in ethylene glycol dimethylether; tert-butyl alcohol T=0 - 20°C; 3.5 h;

1: With N-benzyl quinidinium chloride; cesium hydroxide monohydrate in dichloromethane; toluene T=-30°C; Mannich-type reaction; 60 h; Inert atmosphere; 2: With chloro-trimethyl-silane; magnesium in methanol; ethylene dibromide T=0 - 20°C; Mannich-type reaction; Inert atmosphere; optical yield given as percent eeenantioselective reaction;