反应条件
1: 1.) diisopropylamine, BuLi, 3.) CO2, Br2 2: 2.) aq. KI3 3: 1.) isobutyl chloroformate, triethylamine, 2.) triethylamine / 1.) DMF, 0-5 deg C, 1.5 h, 2.) DMF, RT, 24 h 4: aq. NaOH / 2-methoxy-ethanol / Ambient temperature View Scheme
参考文献
DeGraw; Brown; Tagawa; Kisliuk; Gaumont; Sirotnak
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1227 - 1230