(2E)-3-(4-硝基苯基)-2-丙烯酸乙酯合成路线 （共 77 条）
反应条件
1-n-butyl-3-methylimidazolium tetrafluoroborate
T=80°C; 2 h;
参考文献
Wang, Lei; Huang, Zhizhen
Journal of Chemical Research, 2005 , # 7 p. 446 - 448
反应条件
1: 4-nitro-aniline With tetrafluoroboric acid; sodium nitrite
2: ethyl acrylate With 5-palladium/activated carbon; calcium carbonate in methanol
T=25°C; Heck reaction; 12 h;
参考文献
Felpin, Francois-Xavier; Fouquet, Eric; Zakri, Cecile
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 16 p. 2559 - 2565
反应条件
N,N,N',N'-tetra-methylnaphthalene-1,8-diamine in N,N-dimethyl-formamide
T=20 - 60°C; 39 h;
参考文献
Baudoux, Jerome; Lefebvre, Pierre; Legay, Remi; Lasne, Marie-Claire; Rouden, Jacques
Green Chemistry, 2010 , vol. 12, # 2 p. 252 - 259
反应条件
1: (2,2,7,7-tetramethyl-3,8-dioxo-1,4,6,9-tetraoxa-5λ5-stiba-spiro[4.4]non-5-yl)-acetic acid ethyl ester With lithium diisopropyl amide
T=0°C; deprotonation;
2: 4-nitrobenzaldehdye Wittig type reaction; 3 h; Title compound not separated from byproducts;
参考文献
Kojima, Satoshi; Takagi, Ryukichi; Akiba, Kin-ya
Journal of the American Chemical Society, 1997 , vol. 119, # 25 p. 5970 - 5971
反应条件
in para-xylene
T=140°C; 12 h; Inert atmosphere; optical yield given as percent destereoselective reaction;
参考文献
Fang, Fan; Li, Yuan; Tian, Shi-Kai
European Journal of Organic Chemistry, 2011 , # 6 p. 1084 - 1091
反应条件
palladium diacetate in ethanol; dichloromethane
参考文献
Colas, Christophe; Goeldner, Maurice
European Journal of Organic Chemistry, 1999 , # 6 p. 1357 - 1366
反应条件
sulfuric acid
5 h; Heating;
参考文献
Potapov, V. M.; Gracheva, R. A.; Sivov, N. A.; Savina, S. A.; Sivova, L. A.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 9 p. 1694 - 1699
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 9 p. 1876 - 1881
反应条件
18-crown-6 ether in dimethyl sulfoxide
T=20°C; Kinetics;
参考文献
Appel, Roland; Loos, Robert; Mayr, Herbert
Journal of the American Chemical Society, 2009 , vol. 131, # 2 p. 704 - 714
反应条件
18-crown-6 ether in dimethyl sulfoxide
T=20°C; Kinetics;
参考文献
Appel, Roland; Loos, Robert; Mayr, Herbert
Journal of the American Chemical Society, 2009 , vol. 131, # 2 p. 704 - 714
反应条件
1: 70 percent / isoamyl nitrite / CH2Cl2; acetonitrile / 1 h / -15 °C
2: 45 percent / Pd(OAc)2 / ethanol; CH2Cl2
View Scheme
参考文献
Colas, Christophe; Goeldner, Maurice
European Journal of Organic Chemistry, 1999 , # 6 p. 1357 - 1366
