(E)-3-(1,3-苯并二氧戊环-5-基)丙烯酸乙酯合成路线 （共 33 条）
反应条件
1.1: LiAlH4; AlCl3 / tetrahydrofuran / 1 h / 0 °C 2.1: 83 percent / DIAD; Ph3P / benzene / 1 h / 20 °C 3.1: KOH / methanol / 0.17 h / 0 °C 3.2: 85 percent / methanol / 1 h / 0 °C 4.1: 92 percent / oxone / methanol; H2O / 0 °C 5.1: 82 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Li, Yang; Zhang, Yu; Huang, Zhi; Cao, Xiaoping; Gao, Kun
Canadian Journal of Chemistry, 2004 , vol. 82, # 5 p. 622 - 630
反应条件
1: 82 percent / LiAlH4, EtOH / diethyl ether / 0.5 h / 0 - 5 °C 2: 86 percent / Et3N / CH2Cl2 / 0.5 h / -10 - 0 °C 3: 59 percent / benzene; dimethylformamide / 16 h / Heating 4: 84 percent / H2O, NaCl / dimethylsulfoxide / 3 h / 160 - 165 °C 5: 77 percent / LiAlH4, EtOH / diethyl ether / 0.5 h / 0 - 5 °C 6: 78 percent / pyridinium chlorochromate / CH2Cl2 / 4 h / 10 °C 7: 1.) NaH / 1.) 1,2-dimethoxyethane, 20 deg C, 2.) 1,2-dimethoxyethane, 10 deg C, 4 h, 60 deg C, 1 h View Scheme
参考文献
Bari; Vig; Sattar; Sethi, Madhuresh K.; Sharma
Journal of the Indian Chemical Society, 1996 , vol. 73, # 10 p. 520 - 522
参考文献
Park, Ju-Eun; Lee, Juyeun; Seo, Seung-Yong; Shin, Dongyun
Tetrahedron Letters, 2014 , vol. 55, # 4 p. 818 - 820
反应条件
1: LiAlH4; AlCl3 / tetrahydrofuran / 1 h / 0 °C 2: H2 / Pd/C 3: PCC View Scheme
参考文献
Li, Yang; Zhang, Yu; Huang, Zhi; Cao, Xiaoping; Gao, Kun
Canadian Journal of Chemistry, 2004 , vol. 82, # 5 p. 622 - 630
反应条件
in tetrahydrofuran
6 h; Heating;
参考文献
Aldous, David J.; Batsanov, Andrei S.; Yufit, Dmitrii S.; Dalenon, Anne J.; Dutton, William M.; Steel, Patrick G.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 15 p. 2912 - 2927
反应条件
triethylamine; palladium diacetate in various solvent(s)
T=80°C; Heck reaction; 12 h;
参考文献
Chandrasekhar; Narsihmulu; Shameem Sultana; Ramakrishna Reddy
Organic Letters, 2002 , vol. 4, # 25 p. 4399 - 4401
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride in acetonitrile
T=20°C; Horner-Wadsworth-Emmons reaction; 48 h;
参考文献
Lawrence, Nicholas J; Brown, Stephen
Tetrahedron, 2002 , vol. 58, # 3 p. 613 - 619
反应条件
sulfuric acid
4 h; Cooling with iceReflux;
参考文献
Prashanth; Revanasiddappa, Hosakere D.; Lokanatha Rai; Veeresh
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7065 - 7070
反应条件
1-vanado(V)-11-molybdophosphoric acid; sodium acetate; acetylacetone; palladium diacetate; oxygen in propionic acid
T=70°C; P=760 Torr; 4 h; Title compound not separated from byproducts;
参考文献
Tani, Masayuki; Sakaguchi, Satoshi; Ishii, Yasutaka
Journal of Organic Chemistry, 2004 , vol. 69, # 4 p. 1221 - 1226
反应条件
4-(N,N-dimethlyamino)pyridine; 1,3-bis(2,4,6-trimethylphenyl)imidazolinium chloride in toluene
T=60°C; 2 h;
参考文献
Zeitler, Kirsten
Organic Letters, 2006 , vol. 8, # 4 p. 637 - 640
