(E)-3-(1,3-苯并二氧戊环-5-基)丙烯酸乙酯合成路线 （共 33 条）
反应条件
1: lithium aluminum hydride / diethyl ether
2: 81 percent / N-bromosuccinimide / CH2Cl2
3: 80 percent / sodium cyanoborohydride; tri-n-butyltin chloride / AIBN / 2-methyl-propan-2-ol / Heating
4: 71 percent / Jones reagent / H2O / sonification
View Scheme
参考文献
Srikrishna; Danieldoss
Synthetic Communications, 2001 , vol. 31, # 15 p. 2357 - 2364
反应条件
1.1: LiAlH4; AlCl3 / tetrahydrofuran / 1 h / 0 °C
2.1: 83 percent / DIAD; Ph3P / benzene / 1 h / 20 °C
3.1: KOH / methanol / 0.17 h / 0 °C
3.2: 68 percent / methanol / 1 h / 0 °C
4.1: 94 percent / oxone / methanol; H2O / 0 °C
5.1: 84 percent / KOH; Al2O3; CBr2F2 / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Li, Yang; Zhang, Yu; Huang, Zhi; Cao, Xiaoping; Gao, Kun
Canadian Journal of Chemistry, 2004 , vol. 82, # 5 p. 622 - 630
反应条件
1: hydrogen / 5percent Pd/C / ethanol
2: sodium wire / diethyl ether / 18 h / Ambient temperature
3: 1) NaOMe / 1) MeOH, reflux, 45 min, 2) MeOH, reflux, 18 h
4: ethanol / 24 h / Heating
View Scheme
参考文献
Brown; Blakemore; Durant; Emmett; Ganellin; Parsons; Rawlings; Walker
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 1 p. 53 - 62
