[5-(三丁基锡)噻唑-2-基]氨基甲酸叔丁酯合成路线 （共 3 条）
反应条件
1: 2-t-butoxycarbonylamino-1,3-thiazole With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2: tributyltin chloride in tetrahydrofuran
参考文献
SPHAERA PHARMA PVT. LTD.; DUGAR, Sundeep; MAHAJAN, Dinesh; HOLLINGER PETER, Frank; SHARMA, Amit; TRIPATHI, Vinayak; KUILA, Bilash
Patent: WO2014/16849 A2, 2014 ;
Location in patent: Page/Page column 121; 122 ;
反应条件
1: 2-t-butoxycarbonylamino-1,3-thiazole With n-butyllithium in tetrahydrofuran T=-78°C; 0.75 h; 2: tributyltin chloride in tetrahydrofuran T=-78 - 20°C; 3 h;
参考文献
AMGEN INC.
Patent: US2007/173506 A1, 2007 ;
Location in patent: Page/Page column 54; 55 ;
反应条件
1: triethylamine; 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 16 h / 0 °C 2: lithium diisopropyl amide / tetrahydrofuran / -78 °C View Scheme
