6-[N-(4-氯-2-氟苯基)磺酰基]-1-环己烯-1-羧酸乙酯合成路线 （共 7 条）
反应条件
hydrogen sulfide in ethanol; water
参考文献
Auspex Pharmaceuticals, Inc.
Patent: US2009/22706 A1, 2009 ;
反应条件
triethylamine in ethyl acetate
参考文献
Yamada, Masami; Ichikawa, Takashi; Ii, Masayuki; Sunamoto, Mie; Itoh, Katsumi; Tamura, Norikazu; Kitazaki, Tomoyuki
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7457 - 7467
反应条件
1: 74 percent / Cl2(gas); aq. AcOH / 0.83 h / 15 °C 2: 78 percent / Et3N / ethyl acetate View Scheme
参考文献
Yamada, Masami; Ichikawa, Takashi; Ii, Masayuki; Sunamoto, Mie; Itoh, Katsumi; Tamura, Norikazu; Kitazaki, Tomoyuki
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7457 - 7467
反应条件
1: SOCl2 / 14 h / Heating 2: 78 percent / Et3N / ethyl acetate View Scheme
参考文献
Yamada, Masami; Ichikawa, Takashi; Ii, Masayuki; Sunamoto, Mie; Itoh, Katsumi; Tamura, Norikazu; Kitazaki, Tomoyuki
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7457 - 7467
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6495604 B1, 2002 ;
反应条件
1: 74 percent / Ba(OH)2*8H2O / acetonitrile / 1 h / 60 °C 2: 72 percent / Cs2CO3; tetrabutylammonium iodide / acetonitrile / 2.5 h / 52 - 55 °C 3: Lipase PS-D / acetone; H2O / 17.5 h / 28 °C 4: 72 percent / H2SO4 / 19 h / Heating View Scheme
参考文献
Yamada; Ichikawa; Yamano; Kikumoto; Nishikimi; Tamura; Kitazaki
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 1 p. 58 - 62
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 23 p. 7457 - 7467
