2-(氯磺酰基)环己烯-1-羧酸乙酯合成路线 （共 7 条）
反应条件
chlorine; acetic acid T=15°C; 0.833333 h;
参考文献
Yamada, Masami; Ichikawa, Takashi; Ii, Masayuki; Sunamoto, Mie; Itoh, Katsumi; Tamura, Norikazu; Kitazaki, Tomoyuki
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7457 - 7467
反应条件
thionyl chloride 14 h; Heating;
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6495604 B1, 2002 ;
反应条件
1.1: H2S(gas) / ethanol / 2 h / -50 °C 1.2: HCl(gas) / ethanol / 2 h / -20 °C 1.3: 73 percent / H2S(gas) / ethanol / 16 h / -20 °C 2.1: 74 percent / Cl2(gas); aq. AcOH / 0.83 h / 15 °C View Scheme
参考文献
Yamada, Masami; Ichikawa, Takashi; Ii, Masayuki; Sunamoto, Mie; Itoh, Katsumi; Tamura, Norikazu; Kitazaki, Tomoyuki
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7457 - 7467
反应条件
triethylamine in ethyl acetate
参考文献
Yamada, Masami; Ichikawa, Takashi; Ii, Masayuki; Sunamoto, Mie; Itoh, Katsumi; Tamura, Norikazu; Kitazaki, Tomoyuki
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7457 - 7467
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6495604 B1, 2002 ;
反应条件
triethylamine in ethyl acetate T=0°C; 14.5 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: WO2009/15028 A1, 2009 ;
Location in patent: Page/Page column 66 ;
反应条件
1: 78 percent / Et3N / ethyl acetate 2: 634 mg / HPLC-CHIRALPAK AD View Scheme
参考文献
Yamada, Masami; Ichikawa, Takashi; Ii, Masayuki; Sunamoto, Mie; Itoh, Katsumi; Tamura, Norikazu; Kitazaki, Tomoyuki
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7457 - 7467
