5H-茚并[1,2-b]吡啶合成路线 （共 22 条）
反应条件
hydrazine in diethylene glycol T=168°C; 3 h;
参考文献
CANON KABUSHIKI KAISHA
Patent: US2008/154040 A1, 2008 ;
Location in patent: Page/Page column 27 ;
反应条件
T=800°C; P=0.05 - 0.2 Torr; 0.25 h;
参考文献
Ohsawa, Akio; Kawaguchi, Takayuki; Igeta, Hiroshi
Journal of Organic Chemistry, 1982 , vol. 47, # 18 p. 3497 - 3503
反应条件
hydrazine hydrate T=160 - 170°C; 18 h;
参考文献
Mlochowski, Jacek; Szulc, Zdzislaw
Polish Journal of Chemistry, 1983 , vol. 57, # 1/3 p. 33 - 39
反应条件
1: 18.3 percent / KMnO4; water / Heating 2: 92 percent / PPA / 2.5 h / 210 - 230 °C 3: 57 percent / hydrazine monohydrate / ethane-1,2-diol / 4 h / 180 °C View Scheme
参考文献
DuPriest, Mark T.; Schmidt, Charles L.; Kuzmich, Daniel; Williams, Stanly B
Journal of Organic Chemistry, 1986 , vol. 51, # 11 p. 2021 - 2023
反应条件
1: 92 percent / PPA / 2.5 h / 210 - 230 °C 2: 57 percent / hydrazine monohydrate / ethane-1,2-diol / 4 h / 180 °C View Scheme
参考文献
DuPriest, Mark T.; Schmidt, Charles L.; Kuzmich, Daniel; Williams, Stanly B
Journal of Organic Chemistry, 1986 , vol. 51, # 11 p. 2021 - 2023
反应条件
1: 82 percent / diethyl ether / 1 h / -10 - 25 °C 2: 61 percent / potassium permanganate / H2O / 1.75 h / Heating 3: 98 percent / polyphosphoric acid / 2 h / 210 - 215 °C 4: 98 percent / hydrazine monohydrate / bis-(2-hydroxy-ethyl) ether / 4 h / 180 °C View Scheme
参考文献
DuPriest, Mark T.; Schmidt, Charles L.; Kuzmich, Daniel; Williams, Stanly B
Journal of Organic Chemistry, 1986 , vol. 51, # 11 p. 2021 - 2023
反应条件
1: 82 percent / diethyl ether / 1 h / -10 - 25 °C 2: 61 percent / potassium permanganate / H2O / 1.75 h / Heating 3: 98 percent / polyphosphoric acid / 2 h / 210 - 215 °C 4: 98 percent / hydrazine monohydrate / bis-(2-hydroxy-ethyl) ether / 4 h / 180 °C View Scheme
参考文献
DuPriest, Mark T.; Schmidt, Charles L.; Kuzmich, Daniel; Williams, Stanly B
Journal of Organic Chemistry, 1986 , vol. 51, # 11 p. 2021 - 2023
反应条件
in benzene T=500 - 700°C; 0.5 h;
参考文献
Soldatenkov, A. T.; Bagdadi, M. V.; Radzhan, P. K.; Brindkha, O. S.; Edogiaverie, S. L.; et al.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, # 6 p. 1184 - 1190
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 6 p. 1326 - 1332
反应条件
1: potassium hydroxide; potassium permanganate / water / |Reflux 2: hydrazine hydrate / diethylene glycol / 12 h / 170 °C / |Inert atmosphere View Scheme
参考文献
YEN, FENG-WEN; CHANG, CHENG-HAO; CHANG, HSU-KAI; WANG, FENG-YING
Patent: US2014/151645 A1, 2014 ;
参考文献
The DuPont Merck Pharmaceutical Co.
Patent: US5173489 A1, 1992 ;
