5H-茚并[1,2-b]吡啶合成路线 （共 22 条）
反应条件
sodium amide in various solvent(s) T=190 - 195°C; Chichibabin amination; 5 h;
参考文献
Varlamov; Levov; Toze; Chernyshev; Davydov; Ryabov; Egorova
Chemistry of Heterocyclic Compounds, 2002 , vol. 38, # 12 p. 1484 - 1490
反应条件
N-bromosuccinmide in tetrachloromethane
10 h; Heating;
参考文献
Prostakov, N. S.; Shalimov, V. P.; Montenegro Cordova Galo, B.; Leonova, N. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 11 p. 1213 - 1216
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , # 11 p. 1527 - 1530
反应条件
1: 96 percent / N-bromosuccinimide / CCl4
2: 46 percent / dimethylformamide / 4 h / Ambient temperature
View Scheme
参考文献
Prostakov, N. S.; Shalimov, V. P.; Montenegro Cordova Galo, B.; Leonova, N. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 11 p. 1213 - 1216
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , # 11 p. 1527 - 1530
反应条件
1: 96 percent / N-bromosuccinimide / CCl4
2: 64 percent / dimethylformamide / Ambient temperature
View Scheme
参考文献
Prostakov, N. S.; Shalimov, V. P.; Montenegro Cordova Galo, B.; Leonova, N. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 11 p. 1213 - 1216
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , # 11 p. 1527 - 1530
反应条件
1: 96 percent / N-bromosuccinimide / CCl4 / 4 h / 50 °C
2: 78 percent / dimethylformamide / 4 h / Ambient temperature
View Scheme
参考文献
Prostakov, N. S.; Shalimov, V. P.; Montenegro Cordova Galo, B.; Leonova, N. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 11 p. 1213 - 1216
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , # 11 p. 1527 - 1530
反应条件
1: 96 percent / N-bromosuccinimide / CCl4 / 4 h / 50 °C
2: 64 percent / dimethylformamide / 4 h / Ambient temperature
3: 61 percent / SOCl2 / benzene / 1 h / Ambient temperature
View Scheme
参考文献
Prostakov, N. S.; Shalimov, V. P.; Montenegro Cordova Galo, B.; Leonova, N. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 11 p. 1213 - 1216
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , # 11 p. 1527 - 1530
反应条件
1: 96 percent / N-bromosuccinimide / CCl4 / 4 h / 50 °C
2: 12 percent / aniline / dimethylformamide / 6 h / 50 - 60 °C
View Scheme
参考文献
Prostakov, N. S.; Shalimov, V. P.; Montenegro Cordova Galo, B.; Leonova, N. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 11 p. 1213 - 1216
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , # 11 p. 1527 - 1530
反应条件
lithium aluminium tetrahydride; n-butyllithium in tetrahydrofuran; methanol; hexane
参考文献
Alcon Laboratories, Inc.
Patent: US4864028 A1, 1989 ;
反应条件
sodium hydride; dimethyl sulfoxide
1.) THF, 2.) THF, 1 h; Multistep reaction;
参考文献
Braven, J.; Hanson, R. W.; Smith, N. G.
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 1051 - 1056
反应条件
lithium aluminium tetrahydride; n-butyllithium in tetrahydrofuran; methanol; hexane
参考文献
Alcon Laboratories, Inc.
Patent: US4537892 A1, 1985 ;
