2-(3-溴丙基)-2-甲基-1,3-二氧戊环合成路线 （共 27 条）
反应条件
1: 50.8 percent / LiAlH4 / diethyl ether / 0.5 h / 0 °C
2: 78 percent / LiBr, TMSCl / acetonitrile / 15 h / Heating
3: 96 percent / p-TsOH / benzene / 5 h / Heating
View Scheme
参考文献
Joubert; Beney; Marsura; Luu-Duc
Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 8 p. 745 - 754
反应条件
1: aq. HCl / 4 h / 90 °C
2: 68.4 percent / p-TsOH / benzene / 5 h / Ambient temperature
3: 50.8 percent / LiAlH4 / diethyl ether / 0.5 h / 0 °C
4: 78 percent / LiBr, TMSCl / acetonitrile / 15 h / Heating
5: 96 percent / p-TsOH / benzene / 5 h / Heating
View Scheme
参考文献
Joubert; Beney; Marsura; Luu-Duc
Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 8 p. 745 - 754
反应条件
1: 68.4 percent / p-TsOH / benzene / 5 h / Ambient temperature
2: 50.8 percent / LiAlH4 / diethyl ether / 0.5 h / 0 °C
3: 78 percent / LiBr, TMSCl / acetonitrile / 15 h / Heating
4: 96 percent / p-TsOH / benzene / 5 h / Heating
View Scheme
参考文献
Joubert; Beney; Marsura; Luu-Duc
Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 8 p. 745 - 754
反应条件
lithium bromide in acetone
1.) room temperature, overnight, 2.) reflux, 4 h; Yield given;
参考文献
Joshi, Navalkishore N.; Mamdapur, Vasant R.; Chadha, Mohindra S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2963 - 2966
反应条件
1: HBr; H2O / Heating
2: p-TsOH / benzene / 4 h / Heating
View Scheme
参考文献
Vasil'ev; Serebryakov
Russian Journal of Organic Chemistry, 1998 , vol. 34, # 7 p. 981 - 984
反应条件
1: 44 percent / hexametapol / 0.08 h / 205 °C
2: 65 percent / O2, PdCl2, CuCl / tetrahydrofuran; H2O / 6 h / 60 °C
3: 90 percent / pyridinium tosylate / benzene / 32 h / Heating
View Scheme
参考文献
Odinokov, V. N.; Ishmuratov, G. Yu.; Kharisova, R. Ya.; Vakhidov, R. R.; Botsman, L. P.; Tolstikov, G. A.
Chemistry of Natural Compounds, 1993 , vol. 29, # 2 p. 240 - 244
Khimiya Prirodnykh Soedinenii, 1993 , # 2 p. 288 - 292
反应条件
1: 1.) O3, 2.) NaBH4 / 1.) MeOH, 5 deg C, 2.) MeOH, < 20 deg C, 5 h
2: pyridine
3: NaBr / dimethylformamide / 2 h / 65 °C
View Scheme
参考文献
Odinokov, V. N.; Ishmuratov, G. Yu.; Kharisova, R. Ya.; Vakhidov, R. R.; Botsman, L. P.; Tolstikov, G. A.
Chemistry of Natural Compounds, 1993 , vol. 29, # 2 p. 240 - 244
Khimiya Prirodnykh Soedinenii, 1993 , # 2 p. 288 - 292
反应条件
1: 65 percent / O2, PdCl2, CuCl / tetrahydrofuran; H2O / 6 h / 60 °C
2: 90 percent / pyridinium tosylate / benzene / 32 h / Heating
View Scheme
参考文献
Odinokov, V. N.; Ishmuratov, G. Yu.; Kharisova, R. Ya.; Vakhidov, R. R.; Botsman, L. P.; Tolstikov, G. A.
Chemistry of Natural Compounds, 1993 , vol. 29, # 2 p. 240 - 244
Khimiya Prirodnykh Soedinenii, 1993 , # 2 p. 288 - 292
反应条件
1: LiAlH4
2: 100 percent / Et3N / CH2Cl2 / 2 h / 0 - 5 °C
3: LiBr / acetone / 1.) room temperature, overnight, 2.) reflux, 4 h
View Scheme
参考文献
Joshi, Navalkishore N.; Mamdapur, Vasant R.; Chadha, Mohindra S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2963 - 2966
反应条件
1: pyridine
2: 65 percent / Hg(OAc)2, Jones reagent / acetone
4: LiAlH4
5: 100 percent / Et3N / CH2Cl2 / 2 h / 0 - 5 °C
6: LiBr / acetone / 1.) room temperature, overnight, 2.) reflux, 4 h
View Scheme
参考文献
Joshi, Navalkishore N.; Mamdapur, Vasant R.; Chadha, Mohindra S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2963 - 2966
