2-(3-溴丙基)-2-甲基-1,3-二氧戊环合成路线 （共 27 条）
反应条件
1: 65 percent / Hg(OAc)2, Jones reagent / acetone
3: LiAlH4
4: 100 percent / Et3N / CH2Cl2 / 2 h / 0 - 5 °C
5: LiBr / acetone / 1.) room temperature, overnight, 2.) reflux, 4 h
View Scheme
参考文献
Joshi, Navalkishore N.; Mamdapur, Vasant R.; Chadha, Mohindra S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2963 - 2966
反应条件
2: LiAlH4
3: 100 percent / Et3N / CH2Cl2 / 2 h / 0 - 5 °C
4: LiBr / acetone / 1.) room temperature, overnight, 2.) reflux, 4 h
View Scheme
参考文献
Joshi, Navalkishore N.; Mamdapur, Vasant R.; Chadha, Mohindra S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2963 - 2966
反应条件
sodium hydrogencarbonate; sodium iodide in acetone
4 h; Ambient temperature;
参考文献
Rama Rao, A. V.; Deshmukh, M. N.; Sharma, G. V. M.
Tetrahedron, 1987 , vol. 43, # 4 p. 779 - 784
反应条件
1: 2.) 30percent sodium hydroxide / 1.) toluene, reflux, 2 d; 2.) water, reflux 2h
2: 70 percent / butyl-lithium / tetrahydrofuran / 1.) 0 degC, 15 min, 2.) -78 degC to R. T.
3: 84 percent / 50percent sodium hydride / dimethylformamide / 1 h / 50 °C
View Scheme
参考文献
Cornish, Christopher A.; Warren, Stuart
Tetrahedron Letters, 1983 , vol. 24, # 25 p. 2603 - 2606
反应条件
hydroxide
2.) H2O; Yield given. Multistep reaction;
参考文献
Cornish Christopher A.; Warren, Stuart
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2585 - 2598
反应条件
(i) liq. NH3, (ii) aq. HCl, MeOH; Multistep reaction;
参考文献
Stork,G. et al.
Journal of the American Chemical Society, 1965 , vol. 87, p. 1148 - 1149
参考文献
Salinaro, Richard F.; Berson, Jerome A.
Journal of the American Chemical Society, 1982 , vol. 104, # 8 p. 2228 - 2232
