2-[[3-[(2R)-2-[[(2R)-2-(3-氯苯基)-2-羟基-乙基]氨基]丙基]-1H-吲哚-7-基]氧基]乙酸合成路线 （共 4 条）
反应条件
1: phosphorus oxychloride / 2 h / 20 °C
2: ammonium acetate; Ac2O; AcONa / AcOH / 2 h / Heating
3: LiAlH4 / tetrahydrofuran; diethyl ether / 5.5 h / Heating
4: 47 percent / methanol / 28 h / 20 °C
5: 48 percent / Et3N / tetrahydrofuran / 16 h / 20 °C
6: 77 percent / H2 / Rh/C / ethanol / 36 h / 50 - 55 °C / atmospheric pressure
7: 67 percent / K2CO3; KI / methanol; acetone / 3 h / Heating
8: 73 percent / aq. NaOH / ethanol / 18 h / Heating
View Scheme
参考文献
Harada, Hiroshi; Hirokawa, Yoshimi; Suzuki, Kenji; Hiyama, Yoichi; Oue, Mayumi; Kawashima, Hitoshi; Kato, Hiroshi; Yoshida, Naoyuki; Furutani, Yasuji; Kato, Shiro
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 2 p. 184 - 198
反应条件
1: ammonium acetate; Ac2O; AcONa / AcOH / 2 h / Heating
2: LiAlH4 / tetrahydrofuran; diethyl ether / 5.5 h / Heating
3: 47 percent / methanol / 28 h / 20 °C
4: 48 percent / Et3N / tetrahydrofuran / 16 h / 20 °C
5: 77 percent / H2 / Rh/C / ethanol / 36 h / 50 - 55 °C / atmospheric pressure
6: 67 percent / K2CO3; KI / methanol; acetone / 3 h / Heating
7: 73 percent / aq. NaOH / ethanol / 18 h / Heating
View Scheme
参考文献
Harada, Hiroshi; Hirokawa, Yoshimi; Suzuki, Kenji; Hiyama, Yoichi; Oue, Mayumi; Kawashima, Hitoshi; Kato, Hiroshi; Yoshida, Naoyuki; Furutani, Yasuji; Kato, Shiro
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 2 p. 184 - 198
反应条件
1: 47 percent / methanol / 28 h / 20 °C
2: 48 percent / Et3N / tetrahydrofuran / 16 h / 20 °C
3: 77 percent / H2 / Rh/C / ethanol / 36 h / 50 - 55 °C / atmospheric pressure
4: 67 percent / K2CO3; KI / methanol; acetone / 3 h / Heating
5: 73 percent / aq. NaOH / ethanol / 18 h / Heating
View Scheme
参考文献
Harada, Hiroshi; Hirokawa, Yoshimi; Suzuki, Kenji; Hiyama, Yoichi; Oue, Mayumi; Kawashima, Hitoshi; Kato, Hiroshi; Yoshida, Naoyuki; Furutani, Yasuji; Kato, Shiro
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 2 p. 184 - 198
反应条件
1: LiAlH4 / tetrahydrofuran; diethyl ether / 5.5 h / Heating
2: 47 percent / methanol / 28 h / 20 °C
3: 48 percent / Et3N / tetrahydrofuran / 16 h / 20 °C
4: 77 percent / H2 / Rh/C / ethanol / 36 h / 50 - 55 °C / atmospheric pressure
5: 67 percent / K2CO3; KI / methanol; acetone / 3 h / Heating
6: 73 percent / aq. NaOH / ethanol / 18 h / Heating
View Scheme
参考文献
Harada, Hiroshi; Hirokawa, Yoshimi; Suzuki, Kenji; Hiyama, Yoichi; Oue, Mayumi; Kawashima, Hitoshi; Kato, Hiroshi; Yoshida, Naoyuki; Furutani, Yasuji; Kato, Shiro
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 2 p. 184 - 198
