2-甲基-2-丙基[(2R)-1-苯基-3-丁烯-2-基]氨基甲酸酯合成路线 （共 7 条）
反应条件
1: potassium tert-butylate / toluene / 96 h / |Reflux 2: hydrogenchloride / water; methanol / 4 h 3: N-Acetyl-Dl-leucine / toluene; propan-1-ol / 20 - 95 °C / |Resolution of racemate 4: triethylamine / dichloromethane / 29 h 5: sodium hydrogencarbonate; Oxonereg; / water; acetone; ethyl acetate / 17 h 6: hexane / 1 h / 5 - 45 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 15, # 2 p. 331 - 338
反应条件
1: potassium tert-butylate / toluene / 96 h / |Reflux 2: hydrogenchloride / water; methanol / 4 h 3: N-Acetyl-Dl-leucine / toluene; propan-1-ol / 20 - 95 °C / |Resolution of racemate 4: triethylamine / dichloromethane / 29 h 5: sodium hydrogencarbonate; Oxonereg; / water; acetone; ethyl acetate / 17 h 6: hexane / 1 h / 5 - 45 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 15, # 2 p. 331 - 338
反应条件
Oxonereg;; ammonium acetate; ammonium hydrogen carbonate; lt;meso-tetrakis(2,6-dichlorophenyl)porphyrinatogt;manganese(III) chloride in water; acetonitrile T=20°C; 1 h; Product distribution / selectivity;
参考文献
Che, Chi-Ming; Wong, Man-Kin
Patent: US2005/209470 A1, 2005 ;
Location in patent: Page/Page column 5 ;
反应条件
1: potassium tert-butylate / toluene / 96 h / |Reflux 2: hydrogenchloride / water; methanol / 4 h 3: N-Acetyl-Dl-leucine / toluene; propan-1-ol / 20 - 95 °C / |Resolution of racemate 4: triethylamine / dichloromethane / 29 h View Scheme
参考文献
Blacker, A. John; Roy, Mita; Hariharan, Sivaramkrishanan; Headley, Catherine; Upare, Abhay; Jagtap, Ashutosh; Wankhede, Karuna; Mishra, Sushil Kumar; Dube, Dagadu; Bhise, Sanjay; Vishwasrao, Sandesh; Kadam, Nitin
Organic Process Research and Development, 2011 , vol. 15, # 2 p. 331 - 338
反应条件
Oxonereg;; ammonium acetate; ammonium hydrogen carbonate; lt;meso-tetrakis(2,6-dichlorophenyl)porphyrinatogt;manganese(III) chloride in water; acetonitrile T=20°C; 1 h; Product distribution / selectivity;
参考文献
Che, Chi-Ming; Wong, Man-Kin
Patent: US2005/209470 A1, 2005 ;
Location in patent: Page/Page column 5 ;
反应条件
1: Methyltriphenylphosphonium bromide With potassium hydride; 1,1,1,3,3,3-hexamethyl-disilazane in tetrahydrofuran; dimethyl sulfoxide
T=0°C; 1 h;
2: {(1R)-1-benzyl-2-oxo-ethyl}-carbamic acid tert-butyl ester in tetrahydrofuran; dimethyl sulfoxide
T=-78 - 45°C; Wittig reaction; 16 h;
参考文献
Bakshi, Pancham; Wolfe, Michael S.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 26 p. 6485 - 6489
反应条件
triethylamine in dichloromethane
29 h;
参考文献
Blacker, A. John; Roy, Mita; Hariharan, Sivaramkrishanan; Headley, Catherine; Upare, Abhay; Jagtap, Ashutosh; Wankhede, Karuna; Mishra, Sushil Kumar; Dube, Dagadu; Bhise, Sanjay; Vishwasrao, Sandesh; Kadam, Nitin
Organic Process Research and Development, 2011 , vol. 15, # 2 p. 331 - 338
