1,2,4,5-四甲氧基苯合成路线 （共 37 条）
反应条件
potassium hydroxide in tetrahydrofuran; water Inert atmosphere;
参考文献
Caldwell, Stuart T.; McPhail, Donald B.; Duthie, Garry G.; Hartley, Richard C.
Canadian Journal of Chemistry, 2012 , vol. 90, # 1 p. 23 - 33
反应条件
potassium hydroxide T=100°C;
参考文献
Schmid, Kyle M.; Jensen, Lasse; Phillips, Scott T.
Journal of Organic Chemistry, 2012 , vol. 77, # 9 p. 4363 - 4374
参考文献
PhytoMyco Research Corporation
Patent: US2007/110726 A1, 2007 ;
Location in patent: Page/Page column 19 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50°C; 96 h; Yield given;
参考文献
Keegstra, Erik M. D.; Huisman, Bart-Hendrik; Paardekooper, Elizabeth M.; Hoogesteger, Frans J.; Zwikker, Jan W.; Jenneskens, Leonardus W.; Kooijman, Huub; Schouten, Arie; Veldman, Nora; Spek, Anthony L.
Journal of the Chemical Society. Perkin Transactions 2, 1996 , vol. 2, p. 229 - 240
反应条件
in water T=20 - 25°C; Oxidation; pH=6.0; KineticsEquilibrium constant;
参考文献
Steenken, Steen; Jovanovic, Slobodan V.; Bietti, Massimo; Bernhard, Klaus
Journal of the American Chemical Society, 2000 , vol. 122, # 10 p. 2373 - 2374
反应条件
acetic acid 1) MeOH, electrolyzed, 15 deg C, 2 h, 2) acetone, 45 min, room temperature; Yield given. Multistep reaction. Further byproducts given;
参考文献
Henton, Daniel R.; Anderson, Keith; Manning, Michael J.; Swenton, John S.
Journal of Organic Chemistry, 1980 , vol. 45, # 17 p. 3422 - 3433
反应条件
sulfuric acid anschliessend Behandeln mit wss. NaOH und Dimethylsulfat;
参考文献
Erdtman
Svensk Kemisk Tidskrift, 1932 , vol. 44, p. 135,143, 147
Proceedings of the Royal Society of London, Series A: Mathematical, Physical and Engineering Sciences, 1934 , vol. 143, p. 191,213
反应条件
1: sulfuric acid 2: methanol. H2SO4 / anschliessend Behandeln mit wss. NaOH und Dimethylsulfat View Scheme
参考文献
Erdtman
Svensk Kemisk Tidskrift, 1932 , vol. 44, p. 135,143, 147
Proceedings of the Royal Society of London, Series A: Mathematical, Physical and Engineering Sciences, 1934 , vol. 143, p. 191,213
反应条件
1: benzene; PbO2; MgSO4 2: sulfuric acid 3: methanol. H2SO4 / anschliessend Behandeln mit wss. NaOH und Dimethylsulfat View Scheme
参考文献
Erdtman
Svensk Kemisk Tidskrift, 1932 , vol. 44, p. 135,143, 147
Proceedings of the Royal Society of London, Series A: Mathematical, Physical and Engineering Sciences, 1934 , vol. 143, p. 191,213
反应条件
1.1: 74 percent / HBr; AcOH / 16 h / 20 °C 2.1: Li; NH3 / tetrahydrofuran; H2O / 0.75 h / -78 - -33 °C 2.2: 76 percent / tetrahydrofuran; H2O / 2 h / Heating 3.1: 98 percent / KOtBu / toluene / 4 h / Heating 4.1: 100 percent / HCl / tetrahydrofuran / 12 h / 20 °C 5.1: 89 percent / H2; Et3N / 10percent Pd/C / methanol / 12 h / 20 °C 6.1: 98 percent / KOtBu / toluene / 3 h / Heating 7.1: 4 percent / AgO; HNO3 / dioxane / 20 °C View Scheme
参考文献
Stahl; Kissau; Mazitschek; Huwe; Furet; Giannis; Waldmann
Journal of the American Chemical Society, 2001 , vol. 123, # 47 p. 11586 - 11593
