1: 93 percent / KI, I2, DBU / tetrahydrofuran / 0.67 h / 23 °C 2: 98 percent / nBu3SnH, AIBN / acetonitrile / 0.83 h / Heating 3: 90 percent / K2CO3 / methanol / 0.17 h / 23 °C 4: 99 percent / DCC, Cl2CHCOOH / dimethylsulfoxide / 0.25 h / 23 °C 5: 1.) Py, 2.) DMAP / 1.) MeCN, 0 deg C, 15 min, 2.) 23 deg C, 30 min 6: 88 percent / HCl(gas), HCOOH / toluene / 19 h 7: KOH / H2O; methanol; tetrahydrofuran / 10 h / 100 °C View Scheme

1: 93 percent / KI, I2, DBU / tetrahydrofuran / 0.67 h / 23 °C 2: 98 percent / nBu3SnH, AIBN / acetonitrile / 0.83 h / Heating 3: 90 percent / K2CO3 / methanol / 0.17 h / 23 °C 4: 99 percent / DCC, Cl2CHCOOH / dimethylsulfoxide / 0.25 h / 23 °C 5: 1.) Py, 2.) DMAP / 1.) MeCN, 0 deg C, 15 min, 2.) 23 deg C, 30 min 6: 88 percent / HCl(gas), HCOOH / toluene / 19 h 7: KOH / H2O; methanol; tetrahydrofuran / 10 h / 100 °C 8: tetrahydrofuran View Scheme