1: 60 percent / butyl-lithium / hexane; tetrahydrofuran / 1 h / 0 °C 2: 85 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / Heating 3: 85percent m-chloroperbenzoic acid / CH2Cl2 / 1.5 h / -23 °C View Scheme

tetrachloromethane; water; permanganate(VII) ion

dihydrogen peroxide in acetonitrile T=25°C; 24 h; optical yield given as percent dediastereoselective reaction;

1: α-benzenesulfonyl-phenylacetic acid With sodium hydride in dimethyl sulfoxide T=20°C; 1 h; flushing with nitrogen; 2: methyl iodide in dimethyl sulfoxide T=20°C; 1 h; flushing with nitrogen;

1: PhSO2Et With lithium hexamethyldisilazane in tetrahydrofuran T=-20 - 20°C; Negishi coupling reaction; Inert atmosphere; 2: With zinc(II) chloride in tetrahydrofuran T=-20 - 20°C; Negishi coupling reaction; 1 h; Inert atmosphere; 3: bromobenzene With palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran T=65°C; Negishi coupling reaction; Degassed under vacuumInert atmosphere;

oxygen; rose bengal in methanol Irradiation;

1: dimethylformamide 2: 1.) n-BuLi / 1.) THF View Scheme

1: dimethylformamide 2: 1.) n-BuLi / 1.) THF View Scheme

1.1: NaH / dimethylsulfoxide 1.2: dimethylsulfoxide / 4 h / 20 °C 2.1: KOH / aq. ethanol / 3 h / 40 °C 3.1: NaH / dimethylsulfoxide / 20 °C 3.2: 70 percent / MeSSMe / dimethylsulfoxide / 1 h / 20 °C View Scheme

1.1: KOH / aq. ethanol / 3 h / 40 °C 2.1: NaH / dimethylsulfoxide / 20 °C 2.2: 70 percent / MeSSMe / dimethylsulfoxide / 1 h / 20 °C View Scheme