(7CI,8CI)-m-(对甲苯)-苯甲醚合成路线 （共 44 条）
反应条件
CM-phos; H2O4P(1-)*3K(1+); palladium diacetate; triethylamine in tert-butyl alcohol
T=20 - 110°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Chow, Wing Kin; So, Chau Ming; Lau, Chak Po; Kwong, Fuk Yee
Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5109 - 5112
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; caesium carbonate; palladium dichloride in N,N-dimethyl-formamide
T=185°C; 20 h; Inert atmosphere;
参考文献
Ortgies, Dirk H.; Barthelme, Alexandre; Aly, Sara; Desharnais, Brigitte; Rioux, Steven; Forgione, Pat
Synthesis (Germany), 2013 , vol. 45, # 5 art. no. SS-2012-M0902-OP, p. 694 - 702
反应条件
1: 1-(iodo)-4-methylbenzene With [PdCl2(1,3-bis(diphenylphosphino)propane)]; tBuCH2CH2B(H)NiPr2; triethylamine; potassium iodide in toluene
T=110°C; Suzuki coupling; 1 h; Inert atmosphere;
2: 3-methoxy-iodobenzene With caesium carbonate in ethanol; water; toluene
T=90°C; Suzuki coupling; 15 h; Inert atmosphere;
参考文献
Marciasini, Ludovic; Richy, Nicolas; Vaultier, Michel; Pucheault, Mathieu
Chemical Communications, 2012 , vol. 48, # 10 p. 1553 - 1555
反应条件
[NiCl2(PMe3)2] in tetrahydrofuran
T=25°C; 24 h; Inert atmosphere;
参考文献
Liu, Ning; Wang, Zhong-Xia
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 9 p. 1641 - 1645
反应条件
palladium diacetate; silver nitrate
T=120°C; 48 h; Inert atmosphere;
参考文献
Hong, Wenkun; Qiu, Yatao; Yao, Zhiyi; Wang, Zhaoyang; Jiang, Sheng
Tetrahedron Letters, 2011 , vol. 52, # 38 p. 4916 - 4919
反应条件
sodium hydroxide; Na2[PdCl4]; sodium lauryl sulfate
T=100°C; Hiyama cross-coupling; 0.1 h;
参考文献
Ranu, Brindaban C.; Dey, Raju; Chattopadhyay, Kalicharan
Tetrahedron Letters, 2008 , vol. 49, # 21 p. 3430 - 3432
反应条件
2,2'-bis(di-p-tolyl-phosphino)-1,1'-binaphthyl; copper(I) oxide; 1,10-phenanthroline; palladium (II) bromide in 1-methyl-pyrrolidin-2-one
T=50 - 190°C; Microwave irradiationInert atmosphere;
参考文献
Goossen, Lukas J.; Linder, Christophe; Rodriguez, Nuria; Lange, Paul P.
Chemistry - A European Journal, 2009 , vol. 15, # 37 p. 9336 - 9349
反应条件
tBu2P-N=P(iBuPCH2CH2)3N; tetrabutyl ammonium fluoride; palladium diacetate
T=80°C; Hiyama coupling; 3 h; Inert atmosphereNeat (no solvent);
参考文献
Raders, Steven M.; Kingston, Jesudoss V.; Verkade, John G.
Journal of Organic Chemistry, 2010 , vol. 75, # 5 p. 1744 - 1747
反应条件
[NiCl2(PMe3)2] in tetrahydrofuran
T=60°C; 2 h;
参考文献
Miller, Joseph A.; Dankwardt, John W.; Penney, Jonathan M.
Synthesis, 2003 , # 11 p. 1643 - 1648
反应条件
1: 100 percent / aq. NaOH / toluene
2: 79 percent / 1,1'-bis(diphenylphosphino)ferrocene dichloropalladium / toluene / 24 h / Heating
View Scheme
参考文献
Cammidge, Andrew N.; Goddard, Victoria H. M.; Gopee, Hemant; Harrison, Nicola L.; Hughes, David L.; Schubert, Christopher J.; Sutton, Benjamin M.; Watts, Gary L.; Whitehead, Andrew J.
Organic Letters, 2006 , vol. 8, # 18 p. 4071 - 4074
