triphenylphosphine; [MoO2Cl2(dmf)2] in tetrahydrofuran Heating;

12 h; Ambient temperaturediff. solvents (ethyl acetate, benzene); Product distribution;

4,4'-di-tert-butylbiphenyl; lithium; nickel dichloride in tetrahydrofuran T=20°C; 6 h;

12 h; Ambient temperaturediff. solvents (ethyl acetate, benzene); Product distribution;

sodium carbonate; 2-chloro-imidazoline 1.) CH2Cl2, room temp., 1 h; Yield given. Multistep reaction;

in ethyl acetate 12 h; Ambient temperature;

1: 6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-indole-1-carboxylic acid tert-butyl ester With diethylzinc in toluene T=70°C; 12 h; Inert atmosphere; 2: 3,4-dihydro-isoquinoline 2-oxide; diethylzinc With [(1S)-1-((S)-1-methylpropyl)-(2-morpholin-4-ylethyl)]carbamic acid tert-butyl ester in dichloromethane; toluene T=-30 - -20°C; 24.25 h; Inert atmosphere; 3: With methanol in dichloromethane; toluene T=-20°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;

1: 1,3-dimethoxy-5-pinacolboronate With diethylzinc in toluene T=70°C; 12 h; Inert atmosphere; 2: 3,4-dihydro-isoquinoline 2-oxide; diethylzinc With [(1S)-1-((S)-1-methylpropyl)-(2-morpholin-4-ylethyl)]carbamic acid tert-butyl ester in dichloromethane; toluene T=-30 - -20°C; 24.25 h; Inert atmosphere; 3: With methanol in dichloromethane; toluene T=-20°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;

1: t-butyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl carbonate With diethylzinc in toluene T=70°C; 12 h; Inert atmosphere; 2: 3,4-dihydro-isoquinoline 2-oxide; diethylzinc With [(1S)-1-((S)-1-methylpropyl)-(2-morpholin-4-ylethyl)]carbamic acid tert-butyl ester in dichloromethane; toluene T=-30 - -20°C; 24.25 h; Inert atmosphere; 3: With methanol in dichloromethane; toluene T=-20°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;

Ti(OCH(CH3)2)N(CH2C6H3C(CH3)3O)3; dihydrogen peroxide in methanol; water T=60°C; 0.5 h; Inert atmosphere; regioselective reaction;