(2Z)-2-氰基-N-(2,5-二溴苯基)-3-羟基-2-丁烯酰胺合成路线 （共 3 条）
反应条件
1: N-(2,5-dibromophenyl)-2-cyanoacetamide With sodium hydride in tetrahydrofuran T=-0.15°C; Metallation; 1 h; 2: acetyl chloride in tetrahydrofuran Acylation; 1 h; room t.;
参考文献
Ghosh, Sutapa; Uckun, Fatih M.
Acta Crystallographica Section C: Crystal Structure Communications, 1999 , vol. 55, # 8 p. 1364 - 1365
反应条件
sodium t-butanolate in tetrahydrofuran T=20°C;
参考文献
DuMez, Darin; Venkatachalam, Taracad K.; Uckun, Fatih M.
Arzneimittel-Forschung/Drug Research, 2007 , vol. 57, # 3 p. 155 - 163
反应条件
1: 93 percent / 1,3-diisopropylcarbodiimide / ethyl acetate / 24 h / 20 °C 2: 79 percent / sodium tert-butoxide / tetrahydrofuran / 20 °C View Scheme
参考文献
Tibbles, Heather E.; Samuel, Peter; Erbeck, Doug; Mahajan, Sandeep; Uckun, Fatih M.
Arzneimittel-Forschung/Drug Research, 2004 , vol. 54, # 6 p. 330 - 339
