反应条件
1.1: aq. hydrobromic acid; sodium nitrite / 0.33 h / 0 - 5 °C
1.2: 42 percent / copper(I) bromide; aq. hydrobromic acid / 0.67 h / 60 °C
2.1: tert-butyllithium / diethyl ether; pentane / 1 h / -70 °C
2.2: diethyl ether / 1 h / -70 - 10 °C
3.1: 23.1 g / sodium borohydride / ethanol / 1.5 h / 0 - 20 °C
4.1: thionyl bromide / CH2Cl2 / 1 h / 20 °C
5.1: 3.79 g / aq. sodium sulfite; tetra-n-butylammonium bromide / acetone / 2 h / Heating
6.1: 12 h / 120 °C
6.2: thionyl chloride / 20 °C
View Scheme
参考文献
Michelotti, Enrique L.; Moffett, Kristofer K.; Nguyen, Duyan; Kelly, Martha J.; Shetty, Rupa; Chai, Xiaomei; Northrop, Katrina; Namboodiri, Variketta; Campbell, Brandon; Flynn, Gary A.; Fujimoto, Ted; Hollinger, Frank P.; Bukhtiyarova, Marina; Springman, Eric B.; Karpusas, Michael
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 23 p. 5274 - 5279
