苯并[b]噻吩-3-基乙酸酯合成路线 （共 34 条）
反应条件
1: potassium tert-butylate / dimethyl sulfoxide / 20 °C
2: pyridine / Reflux
View Scheme
参考文献
Hansen, Finn K.; Khankischpur, Mehdi; Tolaymat, Ibrahim; Mesaros, Renata; Dannhardt, Gerd; Geffken, Detlef
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5031 - 5034
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 24 h / 20 °C
2: potassium tert-butylate / dimethyl sulfoxide / 20 °C
3: pyridine / Reflux
View Scheme
参考文献
Hansen, Finn K.; Khankischpur, Mehdi; Tolaymat, Ibrahim; Mesaros, Renata; Dannhardt, Gerd; Geffken, Detlef
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5031 - 5034
反应条件
1: sulfuric acid / 18 h / Reflux; Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; potassium iodide / tetrahydrofuran / 48 h / 20 °C
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 24 h / 20 °C
4: potassium tert-butylate / dimethyl sulfoxide / 20 °C
5: pyridine / Reflux
View Scheme
参考文献
Hansen, Finn K.; Khankischpur, Mehdi; Tolaymat, Ibrahim; Mesaros, Renata; Dannhardt, Gerd; Geffken, Detlef
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5031 - 5034
反应条件
1: N-ethyl-N,N-diisopropylamine; potassium iodide / tetrahydrofuran / 48 h / 20 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 24 h / 20 °C
3: potassium tert-butylate / dimethyl sulfoxide / 20 °C
4: pyridine / Reflux
View Scheme
参考文献
Hansen, Finn K.; Khankischpur, Mehdi; Tolaymat, Ibrahim; Mesaros, Renata; Dannhardt, Gerd; Geffken, Detlef
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5031 - 5034
参考文献
McClelland; D'Silva
Journal of the Chemical Society, 1931 , p. 2972,2975
Full Text Show Details
McClelland
Journal of the Chemical Society, 1929 , p. 1591
反应条件
1: water / Behandeln des Reaktionsprodukts mit Wasser oder wasserfreien Loesungsmitteln, wie Essigester, Aceton oder Nitrobenzol
View Scheme
参考文献
Friedlaender
Justus Liebigs Annalen der Chemie, 1907 , vol. 351, p. 413
参考文献
Hansen, Finn K.; Khankischpur, Mehdi; Tolaymat, Ibrahim; Mesaros, Renata; Dannhardt, Gerd; Geffken, Detlef
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5031 - 5034
参考文献
v. Auwers; Thies
Chemische Berichte, 1920 , vol. 53, p. 2296
参考文献
Bartlett; McClelland
Journal of the Chemical Society, 1934 , p. 818,820
参考文献
D'Silva; McClelland
Journal of the Chemical Society, 1932 , p. 2883,2886
