(S)-3,3,3-二氟-2-羟基-2-甲基丙酸合成路线 （共 5 条）
反应条件
1: With Arthrobacter sp. S-2 in aq. phosphate buffer T=30°C; pH=7; 22 h; Enzymatic reaction; 2: With Shinella sp. R-6 in aq. phosphate buffer T=30°C; pH=7; Reagent/catalyst; enantioselective reaction;
参考文献
Fuhshuku, Ken-Ichi; Watanabe, Shunsuke; Nishii, Tetsuro; Ishii, Akihiro; Asano, Yasuhisa
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 102, p. 115 - 119
参考文献
Tosoh Corporation
Patent: EP1422226 A1, 2004 ;
Location in patent: Page 12 ;
反应条件
whole cells of Escherichia coli containing recombinant Klebsiella oxytoca amidase in aq. buffer T=37°C; pH=8; Large scaleEnzymatic reaction;
参考文献
Organic Process Research and Development, , vol. 6, # 4 p. 497 - 504
反应条件
phosphate buffer 1.5 h; subtilisin carlsberg protease; Yield givenYields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 10, # 4 p. 679 - 687
参考文献
Journal of the Chemical Society, , p. 2329,2330
