1,3-二甲基-1,3-二氢-2H-吲哚-2-酮合成路线 （共 38 条）
反应条件
1: benzene / 1 h / Heating
3: 45 percent / LDA / tetrahydrofuran / 4 h / Ambient temperature; Irradiation
View Scheme
参考文献
Goehring, R. Richard; Sachdeva, Yesh P.; Pisipati, Jyothi S.; Sleevi, Mark C.; Wolfe, James F.
Journal of the American Chemical Society, 1985 , vol. 107, # 2 p. 435 - 443
反应条件
1: 60 percent / pyridine / diethyl ether / 4 h
2: 90 percent / CuBr; N,N,N',N',N''-pentamethyldiethylenetriamine; Cu / benzene / 6 h
3: 65 percent / chlorobenzene / 6 h / 120 °C
View Scheme
参考文献
Leroi, Corinne; Bertin, Denis; Dufils, Pierre-Emmanuel; Gigmes, Didier; Marque, Sylvain; Tordo, Paul; Couturier, Jean-Luc; Guerret, Olivier; Ciufolini, Marco A.
Organic Letters, 2003 , vol. 5, # 26 p. 4943 - 4945
反应条件
1: With potassium tert-butylate
2: With potassium tert-butylate; copper diacetate
3: With ammonium chloride; sodium hydroxide
参考文献
Perry, Alexis; Taylor, Richard J. K.
Chemical Communications, 2009 , # 22 p. 3249 - 3251
反应条件
sodium hydride; benzene
Behandeln des erhaltenen Reaktionsgemisches mit ueberschuessigem Methyljodid;
参考文献
Wenkert et al.
Journal of the American Chemical Society, 1956 , vol. 78, p. 797,798
反应条件
methanol; sodium methylate; methyl iodide
参考文献
Julian et al.
Journal of the American Chemical Society, 1934 , vol. 56, p. 1797,1800
反应条件
hydrogenchloride; tin(ll) chloride in water; acetic acid
T=80°C; Inert atmosphere;
参考文献
Thomson, Jennifer E.; Kyle, Andrew F.; Gallagher, Katherine A.; Lenden, Philip; Concellon, Carmen; Morrill, Louis C.; Miller, Andrew J.; Joannesse, Caroline; Slawin, Alexandra M. Z.; Smith, Andrew D.
Synthesis, 2008 , # 17 art. no. C03008SS, p. 2805 - 2818
反应条件
1: diethyl (2-((2-bromophenyl)(methyl)amino)-2-oxoethyl)phosphonate With KDMO; palladium diacetate in tetrahydrofuran; n-heptane
T=100°C; 0.166667 h; Microwave irradiationInert atmosphere;
2: formaldehyd in tetrahydrofuran; n-heptane
T=100°C; Horner-Wadsworth-Emmons (HWE) olefination; 0.5 h; Microwave irradiation;
3: With sodium tetrahydroborate in tetrahydrofuran; n-heptane
参考文献
Millemaggi, Alessia; Perry, Alexis; Whitwood, Adrian C.; Taylor, Richard J. K.
European Journal of Organic Chemistry, 2009 , # 18 p. 2947 - 2952
反应条件
methyllithium; calcium carbonate
T=250 - 280°C; P=120 Torr; und unterwirft das Destillat nochmals derselben Behandlung;
参考文献
Brunner
Monatshefte fuer Chemie, 1896 , vol. 17, p. 484
反应条件
in toluene
24 h; Reflux;
参考文献
Hisler, Kevin; Commeureuc, Aurelien G.J.; Zhou, Sheng-ze; Murphy, John A.
Tetrahedron Letters, 2009 , vol. 50, # 26 p. 3290 - 3293
反应条件
ethanol; palladium
Hydrogenation;
参考文献
Wenkert et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 3763,3766
