8,9-二氢-6H-吡啶并[2,1-b]喹唑啉-11(7h)-酮合成路线 （共 42 条）
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; Pd(OAc)2*PPh3; potassium carbonate
T=110°C; P=3800 Torr; 24 h;
参考文献
Mori, Miwako; Kobayashi, Hiromi; Kimura, Masaya; Ban, Yoshio
Heterocycles, 1985 , vol. 23, # 11 p. 2803 - 2806
反应条件
1: Et3N / tetrahydrofuran / 20 °C
2: 90 percent / sodium iodide; acetic acid / 3 h / Heating
View Scheme
参考文献
Kamal, Ahmed; Ramana, A. Venkata; Reddy, K. Srinivasa; Ramana, K. Venkata; Hari Babu; Prasad, B. Rajendra
Tetrahedron Letters, 2004 , vol. 45, # 44 p. 8187 - 8190
反应条件
1: benzene; dioxane / 3 h / 20 °C
2: H2SO4 / 8 h / 20 °C
3: 2.484 g / NaBH4 / tetrahydrofuran / 3 h / Heating
4: 81 percent / NaH; p-toluenesulfonyl chloride / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Mhaske, Santosh B.; Argade, Narshinha P.
Tetrahedron, 2004 , vol. 60, # 15 p. 3417 - 3420
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; Pd(OAc)2*PPh3; potassium carbonate
T=110°C; P=3800 Torr; 24 h;
参考文献
Mori, Miwako; Kobayashi, Hiromi; Kimura, Masaya; Ban, Yoshio
Heterocycles, 1985 , vol. 23, # 11 p. 2803 - 2806
参考文献
Koekoesi, Jozsef; Hermecz, Istvan; Szasz, Gyoergy; Meszaros, Zoltan
Tetrahedron Letters, 1981 , vol. 22, # 48 p. 4861 - 4862
反应条件
1: SOCl2 / benzene; dimethylformamide / 5 h / 20 °C
2: Et3N / tetrahydrofuran / 2 h
3: NaI; TMSCl / acetonitrile / 0.25 h / 20 °C
View Scheme
参考文献
Kamal; Ramana; Rao
Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 997 - 1001
反应条件
1: 85 percent
2: 92 percent
View Scheme
参考文献
Koekoesi, Jozsef; Hermecz, Istvan; Szasz, Gyoergy; Meszaros, Zoltan
Tetrahedron Letters, 1981 , vol. 22, # 48 p. 4861 - 4862
反应条件
in toluene
2 h; Heating;
参考文献
Dunn, A. D.; Kinnear, K. I.
Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 53 - 57
反应条件
0.116667 h; microwave irradiation;
参考文献
Yadav; Reddy
Tetrahedron Letters, 2002 , vol. 43, # 10 p. 1905 - 1907
反应条件
1: potassium carbonate / methanol; water / 4 h / 20 °C
2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 3 h / 20 °C
View Scheme
参考文献
Fang, Jie; Zhou, Jianguang
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 12 p. 2389 - 2391
