N-[(2R,3S)-3-氨基-2-羟基-4-苯基丁基]-N-(2-甲基丙基)-4-硝基- 苯磺酰胺盐酸盐合成路线 (共 3 条)
反应条件
hydrogenchloride in 1,4-dioxane T=0 - 20°C;
参考文献
AMPLYX PHARMACEUTICALS, INC.; MUTZ, Mitchell; BARR, Kenneth, J.; GESTWICKI, Jason
Patent: WO2010/77317 A2, 2010 ;
Location in patent: Page/Page column 108; 109 ;
WO 2010/077317 A2
反应条件
1: triethylamine / dichloromethane / 1 h / 15 - 30 °C 2: hydrogenchloride / ethanol; water / 1 h / 75 - 80 °C View Scheme
参考文献
AUROBINDO PHARMA LIMITED; KAMAT, Anand Gopalkrishna; NAGA TRINADHACHARI, Ganala; VENKATA BALAJI, Boddu; JOSEPH PRABAHAR, Koilpillai; MEENAKSHISUNDERAM, Sivakumaran
Patent: WO2013/108105 A2, 2013 ;
反应条件
1: 3 h / 70 - 75 °C 2: triethylamine / dichloromethane / 1 h / 15 - 30 °C 3: hydrogenchloride / ethanol; water / 1 h / 75 - 80 °C View Scheme
参考文献
AUROBINDO PHARMA LIMITED; KAMAT, Anand Gopalkrishna; NAGA TRINADHACHARI, Ganala; VENKATA BALAJI, Boddu; JOSEPH PRABAHAR, Koilpillai; MEENAKSHISUNDERAM, Sivakumaran
Patent: WO2013/108105 A2, 2013 ;