4-氯吡啶-2-甲酸甲酯合成路线 （共 44 条）
反应条件
1: 77 percent / AlMe3 / CH2Cl2; heptane / 24 h / Heating 2: 88 percent / LDA, I2 / tetrahydrofuran / 1.5 h / -78 °C View Scheme
参考文献
Nora De Souza, Marcus V.; Dodd, Robert H.
Heterocycles, 1998 , vol. 47, # 2 p. 811 - 827
反应条件
1: tetrahydrofuran 2: potassium tert-butylate; potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 - 90 °C / |Inert atmosphere View Scheme
参考文献
Yao, Jianwen; He, Zuopeng; Chen, Jing; Sun, Wei; Fang, Hao; Xu, Wenfang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6549 - 6553,5
反应条件
1.1: water / 0.25 h 1.2: 1 h / 20 °C 2.1: sodium hydroxide; bromine / water / 0.58 h / 0 - 5 °C 3.1: sulfuric acid; nitric acid / 0 - 20 °C View Scheme
参考文献
Wang, Jun; Zhan, Peng; Li, Zhenyu; Liu, Huiqing; De Clercq, Erik; Pannecouque, Christophe; Liu, Xinyong
European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 531 - 538
参考文献
Vera, Matthew D.; Lundquist IV, Joseph T.; Chengalvala, Murty V.; Cottom, Joshua E.; Feingold, Irene B.; Garrick, Lloyd M.; Green, Daniel M.; Hauze, Diane B.; Mann, Charles W.; Mehlmann, John F.; Rogers, John F.; Shanno, Linda; Wrobel, Jay E.; Pelletier, Jeffrey C.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 8 p. 2512 - 2515
参考文献
Spaeth; Spitzer
Chemische Berichte, 1926 , vol. 59, p. 1479,1482
Full Text Show Details
Meyer; Graf
Chemische Berichte, 1928 , vol. 61, p. 2211
反应条件
1: 110 °C 2: hydrogenchloride; water / 7 h / 110 °C View Scheme
参考文献
WO2012/3544 A1, ;
WO 2012/003544 A1
反应条件
(i), (ii) aq. HCl; Multistep reaction;
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 32, p. 231 - 234
反应条件
sodium tetrahydroborate; calcium chloride in tetrahydrofuran; methanol T=0°C; 1 h;
参考文献
Ishida, Yoshiyuki; Inoue, Masa-Aki; Inoue, Tomonori; Ojida, Akio; Hamachi, Itaru
Chemical Communications, 2009 , # 20 p. 2848 - 2850
反应条件
methanol; hydrazine hydrate
参考文献
Graf
Chemische Berichte, 1931 , vol. 64, p. 21,26
Full Text Show Details
Mosher; Look
Journal of Organic Chemistry, 1955 , vol. 20, p. 283,285
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran T=-78°C; 2 h; 2: With methanol; Sodium potassium tartrate in tetrahydrofuran T=-78 - 20°C; 1 h;
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US2004/186114 A1, 2004 ;
Location in patent: Page/Page column 69; 70 ;
