4-氯吡啶-2-甲酸甲酯合成路线 （共 44 条）
参考文献
Yao, Jianwen; He, Zuopeng; Chen, Jing; Sun, Wei; Fang, Hao; Xu, Wenfang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6549 - 6553,5
反应条件
palladium in N-methyl-acetamide; ethanol
参考文献
F. HOFFMANN-LA ROCHE LTD; EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL); SAVIRA PHARMACEUTICALS GMBH; CLASSEN-HOUBEN, Dirk; WOLKERSTORFER, Andrea; SZOLAR, Oliver; SMITH, Mark; SO, Sung-Sau; CUSACK, Stephen; LANGER, Thierry; GIETHLEN, Bruno; MORICE, Christophe; MICHAUT-SIMON, Céline; ZUBIETA, Chloe
Patent: US2013/102600 A1, 2013 ;
反应条件
1.1: tetrahydrofuran; methanol / 3 h / 2 - 20 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 2.2: 10 h / 80 - 85 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 9 p. 2923 - 2929
反应条件
trimethylaluminum in n-heptane; dichloromethane 24 h; Heating;
参考文献
Nora De Souza, Marcus V.; Dodd, Robert H.
Heterocycles, 1998 , vol. 47, # 2 p. 811 - 827
反应条件
1.1: potassium carbonate / tetrahydrofuran / 20 h / 20 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C 2.2: 20 - 80 °C 3.1: dichloromethane / 16 h / 20 °C 3.2: 18 h / 20 °C View Scheme
反应条件
1.1: ammonium hydroxide / 3 h / 20 °C 2.1: bromine; sodium hydroxide / water / 5 h / 20 - 80 °C 2.2: pH 12 - 13 View Scheme
参考文献
Wang, Jun; Zhan, Peng; Li, Zhenyu; Liu, Huiqing; De Clercq, Erik; Pannecouque, Christophe; Liu, Xinyong
European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 531 - 538
反应条件
sodium methylate Erwaermen des Reaktionsprodukts mit N2H4+H2O in Methanol;
参考文献
Mosher; Look
Journal of Organic Chemistry, 1955 , vol. 20, p. 283,285
反应条件
1: tert-butyl alcohol With n-butyllithium in tetrahydrofuran; hexane T=0 - 20°C; 2: 4-chloro-pyridine-2-carboxylic acid methyl ester in tetrahydrofuran; hexane T=20°C;
参考文献
KinaGen, Inc.
Patent: US2009/12091 A1, 2009 ;
Location in patent: Page/Page column 46-47 ;
US 20090012091 A1
反应条件
1.1: potassium carbonate / tetrahydrofuran / 20 h / 20 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C 2.2: 20 - 80 °C View Scheme
参考文献
SUZHOU ZELGEN BIOPHARMACEUTICAL CO., LTD; Feng, Weidong; Gao, Xiaoyong; Dai, Xiaojun
Patent: US2013/60043 A1, 2013 ;
反应条件
in tetrahydrofuran; methanol
T=2 - 20°C;
参考文献
Yao, Jianwen; Chen, Jing; He, Zuopeng; Sun, Wei; Xu, Wenfang
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 9 p. 2923 - 2929
