5,7-二氯-1H-咪唑并[4,5-b]吡啶合成路线 （共 4 条）
反应条件
trichlorophosphate in N,N-dimethyl-formamide T=0 - 120°C; 3 h;
参考文献
GLAXOSMITHKLINE LLC; RIVERO, Ralph, A.; TEDESCO, Rosanna
Patent: WO2013/95761 A1, 2013 ;
Location in patent: Page/Page column 32; 33; 34 ;
反应条件
1: 67 percent / trifluoroacetic acid; HNO3 / 3 h / 90 °C 2: 80 percent / POCl3 / dimethylformamide / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 4 p. 828 - 834
反应条件
1: 96 percent / aq. H2O2; acetic acid / 19 h / 60 - 70 °C 2: 67 percent / trifluoroacetic acid; HNO3 / 3 h / 90 °C 3: 80 percent / POCl3 / dimethylformamide / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 4 p. 828 - 834
参考文献
Journal of Heterocyclic Chemistry, , vol. 17, # 8 p. 1757 - 1760
