3-(4-吡啶)-2-丙酸乙酯合成路线 （共 5 条）
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in tetrahydrofuran T=0°C; 0.5 h; 2: pyridine-4-carbaldehyde in tetrahydrofuran 1 h;
参考文献
EP1489078 A1, ;
Page 183 ;
EP 1489078 A1
反应条件
potassium carbonate in ethanol T=70°C; Condensation; 2.5 h;
参考文献
Rango, Rino; Marshall, Garland R.; Santo, Roberto Di; Costi, Roberta; Massa, Silvio; Rompei, Raffaello; Artico, Marino
Bioorganic & Medicinal Chemistry, 2000 , vol. 8, # 6 p. 1423 - 1432
反应条件
sulfuric acid 36 h; Reflux;
参考文献
Journal of Heterocyclic Chemistry, , vol. 50, # 6 p. 1410 - 1414
反应条件
sodium hydride in diethyl ether; dimethyl sulfoxide T=20°C; Cycloaddition; elimination; 0.25 h;
参考文献
Bioorganic & Medicinal Chemistry, , vol. 8, # 6 p. 1423 - 1432
反应条件
1.1: potassium hydroxide / water; diethyl ether / 0.17 h / 0 °C 1.2: 0 - 25 °C 2.1: bromine / diethyl ether / 0.17 h / 25 °C 3.1: hydrogenchloride / water / 3 h / |Reflux View Scheme
参考文献
Janin, Yves L.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1410 - 1414
