(7CI,8CI,9CI)-吡啶并[1,2-a]苯并咪唑合成路线 （共 34 条）
反应条件
potassium permanganate in water 2 h; Heating;
参考文献
Prostakov, N. S.; Varlamov, A. V.; N'ende, D. L. S.; Krapivko, A. P.; Fomichev, A. A.; et al.
Journal of Organic Chemistry USSR (English Translation), 1990 , vol. 26, # 6 p. 1166 - 1170
Zhurnal Organicheskoi Khimii, 1990 , vol. 26, # 6 p. 1351 - 1356
反应条件
1: 87 percent / HNO3, H2SO4 / 1 h / Ambient temperature 2: 54 percent / aq. sodium sulfide / ethanol / 5 h / Heating View Scheme
参考文献
Prostakov, N. S.; Varlamov, A. V.; N'ende, D. L. S.; Krapivko, A. P.; Fomichev, A. A.; et al.
Journal of Organic Chemistry USSR (English Translation), 1990 , vol. 26, # 6 p. 1166 - 1170
Zhurnal Organicheskoi Khimii, 1990 , vol. 26, # 6 p. 1351 - 1356
反应条件
potassium phosphate; palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; sodium t-butanolate in toluene
T=140°C; 24 h; Molecular sieve;
参考文献
BLEND THERAPEUTICS; BILODEAU, Mark, T.; DUNBAR, Craig, A.; BARDER, Timothy, E.; LEE, Edward, R.; ALARGOVA, Rossitza, G.; ROCKWOOD, Danielle, N.; MOREAU, Benoit; SHINDE, Rajesh; BOUTHILLETTE, Melaney
Patent: WO2014/43243 A2, 2014 ;
Location in patent: Paragraph 00249 ;
反应条件
copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine in acetonitrile
T=80°C; 24 h; Inert atmosphere;
参考文献
Liubchak, Kostiantyn; Nazarenko, Kostiantyn; Tolmachev, Andrey
Tetrahedron, 2012 , vol. 68, # 14 p. 2993 - 3000
反应条件
oxygen; copper (II) acetate monohydrate; 3,4,5-trifluoro-benzoic acid in dimethyl sulfoxide
T=120°C; 24 h;
参考文献
He, Yimiao; Huang, Jinbo; Liang, Dongdong; Liu, Lanying; Zhu, Qiang
Chemical Communications, 2013 , vol. 49, # 66 p. 7352 - 7354
反应条件
potassium tert-butylate; ammonia
0.25 h; Irradiation; Reagent/catalystTime;
参考文献
Barolo, Silvia M.; Wang, You; Rossi, Roberto A.; Cuny, Gregory D.
Tetrahedron, 2013 , vol. 69, # 26 p. 5487 - 5494
反应条件
copper(l) iodide; 1,10-phenanthroline; caesium carbonate in anhydrous xylene
T=120°C; Ullmann type reaction; 12 h; Inert atmosphere;
参考文献
Wu, Zhiqing; Huang, Qing; Zhou, Xiangge; Yu, Lintao; Li, Zhengkai; Wu, Di
European Journal of Organic Chemistry, 2011 , # 27 p. 5242 - 5245
反应条件
copper(l) iodide; 1,10-phenanthroline; caesium carbonate in anhydrous xylene
T=120°C; Ullmann type reaction; 24 h; Inert atmosphere;
参考文献
Wu, Zhiqing; Huang, Qing; Zhou, Xiangge; Yu, Lintao; Li, Zhengkai; Wu, Di
European Journal of Organic Chemistry, 2011 , # 27 p. 5242 - 5245
反应条件
PhI(OPiv)2
T=25°C; 2.5 h;
参考文献
Liang, Dongdong; He, Yimiao; Liu, Lanying; Zhu, Qiang
Organic Letters, 2013 , vol. 15, # 13 p. 3476 - 3479
反应条件
hexafluoroisopropyl alcohol; PhI(OPiv)2
T=25°C; 7 h; Reagent/catalystSolvent;
参考文献
Liang, Dongdong; He, Yimiao; Liu, Lanying; Zhu, Qiang
Organic Letters, 2013 , vol. 15, # 13 p. 3476 - 3479
