4-羟基-3-甲氧基-2-硝基苯甲醛合成路线 （共 31 条）
反应条件
1: K2CO3 / dioxane / Heating 2: (i) aq. KOH, EtOH, (ii) Ac2O, NaOAc View Scheme
参考文献
Julia,M. et al.
Bulletin de la Societe Chimique de France, 1965 , p. 1417 - 1423
反应条件
potassium carbonate in N,N-dimethyl-formamide 16 h;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; SCOTT, William; LIU, Ningshu; MOeWES, Manfred
Patent: WO2012/62748 A1, 2012 ;
Location in patent: Page/Page column 56 ;
WO 2012/062748 A1
参考文献
Julia,M. et al.
Bulletin de la Societe Chimique de France, 1965 , p. 1417 - 1423
反应条件
1: concentrated KOH-solution 2: sulfuric acid / 135 - 140 °C View Scheme
参考文献
Jona
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1912 , vol. <5> 21 II, p. 207
反应条件
1: aqueous KOH 2: Raney nickel; ethyl acetate / Hydrogenation 3: sodium ethylate; ethanol 4: pyridine hydrochloride / 200 - 220 °C View Scheme
参考文献
Ried et al.
Chemische Berichte, 1952 , vol. 85, p. 204,212
反应条件
1: ethanolic NaOH 2: pyridine; aqueous potassium permanganate solution View Scheme
参考文献
Raiford; Port; Perry
Journal of the American Chemical Society, 1949 , vol. 71, p. 3851
反应条件
1: concentrated KOH-solution 2: tin; concentrated hydrochloric acid; alcohol View Scheme
参考文献
Jona
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1912 , vol. <5> 21 II, p. 207
反应条件
2: acetone; permanganate
3: carbon disulfide; phosphorus pentachloride
4: carbon disulfide; ammonia
5: sodium hypobromite / 40 °C
6: iron; diluted acetic acid
View Scheme
参考文献
Pisovschi
Chemische Berichte, 1910 , vol. 43, p. 2140
反应条件
ammonia; iodine in tetrahydrofuran; water
48 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2008/70150 A1, 2008 ;
Location in patent: Page/Page column 83 ;
WO 2008/070150 A1
反应条件
1: 79 percent / 1.) FeSO4, aq. HCl, 2.) 15 N ammonium hydroxide; / 90 °C
2: 1.) aq. HCl, NaNO2, 2.) Cu2Cl2; / 1.) water, 0 deg C, 2.) temperature below 5 deg C, 3.) heating on steam bath, 1 h;
View Scheme
参考文献
Ross; Franz; Wilson; et al.
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 6 p. 1805 - 1814
