4-羟基-6-巯基吡唑(3,4-D)嘧啶合成路线 (共 11 条)
参考文献
Journal of the American Chemical Society, , vol. 79, p. 6407,6412
参考文献
Journal of the American Chemical Society, , vol. 78, p. 784,787
Journal of the American Chemical Society, , vol. 79, p. 6407,6413
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 22, # 5-8 p. 967 - 972
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 23 p. 7180 - 7184
反应条件
1: aq. NaOH solution 2: N,N-dimethyl-aniline; POCl3 3: palladium/charcoal; aq.-ethanolic NH3 / Hydrogenation View Scheme
参考文献
Robins
Journal of the American Chemical Society, 1956 , vol. 78, p. 784,787
Journal of the American Chemical Society, 1957 , vol. 79, p. 6407,6413
反应条件
1: 1.) aq. NaOH / 1.) EtOH, from 50 deg C to 60 deg C, 30 min, 2.) EtOH, reflux, 4.5 h 2: 30 percent / conc. aq. sulphuric acid / 120 h View Scheme
参考文献
Russo, F; Guccione, S; Romeo, G; Barretta, G Uccello; Pucci, S; et al.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 5 p. 363 - 376
反应条件
1: 80 percent / Na2CO3 / acetone / 24 h 2: 98 percent / conc. aq. sulphuric acid / 120 h View Scheme
参考文献
Russo, F; Guccione, S; Romeo, G; Barretta, G Uccello; Pucci, S; et al.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 5 p. 363 - 376
反应条件
1: 70 percent / Na2CO3 / acetone / 24 h 2: 90 percent / conc. aq. sulphuric acid / 120 h View Scheme
参考文献
Russo, F; Guccione, S; Romeo, G; Barretta, G Uccello; Pucci, S; et al.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 5 p. 363 - 376
反应条件
1: aq. NaOH solution
2: N,N-dimethyl-aniline; POCl3
View Scheme
参考文献
Kim, Dong Chan; Lee, Yeo Ran; Yang, Beom-Seok; Shin, Kye Jung; Kim, Dong Jin; Chung, Bong Young; Yoo, Kyung Ho
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 5 p. 525 - 532
反应条件
1: 99 percent / NaOH
2: 92 percent / POCl3; PhNMe2
3: 95 percent / iPr2NEt / butan-1-ol / 24 h / 50 °C
View Scheme
参考文献
Kim, Dong Chan; Lee, Yeo Ran; Yang, Beom-Seok; Shin, Kye Jung; Kim, Dong Jin; Chung, Bong Young; Yoo, Kyung Ho
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 5 p. 525 - 532