(4S)-4-苄基-3-(苯基乙酰基)-1,3-恶唑烷-2-酮合成路线 （共 3 条）
反应条件
1: 74 percent / Et3N; DPPA / toluene / 6.5 h / Heating 2: 91 percent / Me2S / CH2Cl2; trifluoroacetic acid / 3 h / 20 °C View Scheme
参考文献
Evans, David A.; Wu, Leester D.; Wiener, John J. M.; Johnson, Jeffrey S.; Ripin, David H. B.; Tedrow, Jason S.
Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6411 - 6417
反应条件
Multi-step reaction with 2 steps 1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 - -50 °C / Inert atmosphere2: dihydrogen peroxide; lithium hydroxide hydrate / tetrahydrofuran; water / 3 h / 0 - 20 °C / Inert atmosphere
参考文献
Chung, Yu-Chiang; Janmanchi, Damodar; Wu, Hsyueh-Liang Organic Letters, 2012 , vol. 14, # 11 p. 2766 - 2769
反应条件
Multi-step reaction with 2 steps 1: 89 percent / NaN(SiMe3)2 / tetrahydrofuran / 2 h / -78 °C2: 89 percent / H2O2; LiOH / tetrahydrofuran; H2O / 1.5 h / 0 °C
参考文献
Evans, David A.; Wu, Leester D.; Wiener, John J. M.; Johnson, Jeffrey S.; Ripin, David H. B.; Tedrow, Jason S. Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6411 - 6417
