4-(1H-吡唑并[3,4-d]-4-嘧啶)-哌嗪-1-羧酸叔丁酯合成路线 (共 4 条)
反应条件
N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one T=80°C;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2005/51304 A2, 2005 ;
Location in patent: Page/Page column 162-163 ;
WO 2005/051304 A2
反应条件
triethylamine in N-methyl-acetamide
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US6423716 B1, 2002 ;
反应条件
1: 1H-pyrazolo[3,4-d]pyrimidin-4-ylamine With 1,1-dibromomethane; isopentyl nitrite 6.5 h; Heating; 2: piperazine-1-carboxylic acid tert-butyl ester With triethylamine in N,N-dimethyl-formamide T=20°C;
参考文献
Matsuno, Kenji; Ushiki, Junko; Seishi, Takashi; Ichimura, Michio; Giese, Neill A.; Yu, Jin-Chen; Takahashi, Shusuke; Oda, Shoji; Nomoto, Yuji
Journal of Medicinal Chemistry, 2003 , vol. 46, # 23 p. 4910 - 4925
反应条件
trifluoroacetic acid in dichloromethane
1.5 h; cooling;
参考文献
Matsuno, Kenji; Ushiki, Junko; Seishi, Takashi; Ichimura, Michio; Giese, Neill A.; Yu, Jin-Chen; Takahashi, Shusuke; Oda, Shoji; Nomoto, Yuji
Journal of Medicinal Chemistry, 2003 , vol. 46, # 23 p. 4910 - 4925