1: 92 percent / KBH4 / ethanol; CH2Cl2 / 5 h / 20 °C 2: 85 percent / HBr / H2O / 5 h / Heating 3: 59 percent / 72 h / Heating View Scheme

1: 85 percent / HBr / H2O / 5 h / Heating 2: 59 percent / 72 h / Heating View Scheme

T=120°C; Inert atmosphere;

1.1: trichlorophosphate / 1 h / 0 - 20 °C / Inert atmosphere 1.2: 100 °C / Inert atmosphere 1.3: 100 °C / Inert atmosphere; Cooling with ice 2.1: sodium tetrahydroborate / methanol / 5 h / Reflux 3.1: hydrogen bromide / chloroform / 48.33 h / 20 °C 4.1: 120 °C / Inert atmosphere View Scheme

Michaelis-Arbuzov reaction; 72 h; Heating;