N-(6-溴己基)邻苯二甲酰亚胺合成路线 （共 43 条）
反应条件
1: K2CO3 / dioxane / 20 °C 2: H2NNH2 / methanol / 20 °C View Scheme
参考文献
Schultes, Christoph M.; Guyen, Berangere; Cuesta, Javier; Neidle, Stephen
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 16 p. 4347 - 4351
反应条件
24-stdg. Kochen. Kochen des Reaktionsprodukts mit konz. HCl.;
参考文献
Breslow et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 102
Full Text Show Details
Breslow; Hauser
Journal of the American Chemical Society, 1945 , vol. 67, p. 687
参考文献
Budzikiewicz, Herbert; Vieth, Peter-Eric; Krueger, Uwe
Monatshefte fuer Chemie, 1981 , vol. 112, p. 825 - 840
反应条件
(i) KOH, MeOH, (ii) aq. KOH, (heating); Multistep reaction;
参考文献
Ledochowski,A. et al.
Roczniki Chemii, 1969 , vol. 43, # 5 p. 1083 - 1087
反应条件
1: Na2S2O3 / methanol; H2O / 4 h / Heating 2: 1.98 g / I2 / methanol; H2O / Heating 3: hydrazine hydrate / ethanol / 1 h / Heating View Scheme
参考文献
Pfammatter, Michael J.; Siljegovic, Vuk; Darbre, Tamis; Keese, Reinhart
Helvetica Chimica Acta, 2001 , vol. 84, # 3 p. 678 - 689
反应条件
1: 90.6 percent / toluene / 15 h / Heating
2: 1) t-BuOK / 1) -78 deg C, THF, 2a) -78 deg C, 7h, 2b) -78 deg C to RT, overnight
3: 39 percent / hydrazine hydrate / ethanol
4: 20 percent / pyridine / dimethylaminopyridine / Ambient temperature
5: 64 percent / methanolic ammonia
View Scheme
参考文献
Agathocleous, Demetrios C.; Bulman Page, Philip C.; Cosstick, Richard; Galpin, Ian J.; McLennan, Alexander G.; Prescott, Mark
Tetrahedron, 1990 , vol. 46, # 6 p. 2047 - 2058
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2: hydrazine hydrate / ethanol / 4 h / Reflux
View Scheme
参考文献
Shan, Wen-Jun; Huang, Ling; Zhou, Qi; Meng, Fan-Chao; Li, Xing-Shu
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 5885 - 5893
反应条件
2: N2H4
4: LiAlH4
View Scheme
参考文献
Budzikiewicz, Herbert; Vieth, Peter-Eric; Krueger, Uwe
Monatshefte fuer Chemie, 1981 , vol. 112, p. 825 - 840
反应条件
water; sodium sulfite
anschliessend mit wss. Na2CO3;
参考文献
Deng, Hong; Liu, Xin; Xie, Jie; Yin, Rong; Huang, Naiyan; Gu, Ying; Zhao, Jingquan
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1910 - 1919
反应条件
1: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 100 deg C, 8 h
2: 1.) hydrazine hydrate, 2.) 4 N aq. HCl / 1.) EtOH, reflux, 8 h, 2.) EtOH, reflux, 6 h
View Scheme
参考文献
Wright Jr.; Press; Chan; Marsico; Haug; Lucas; Tauber; Tomcufcik
Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 523 - 530
