N-(6-溴己基)邻苯二甲酰亚胺合成路线 （共 43 条）
反应条件
1: sodium sulfite / ethanol; water / |Reflux
2: phosphorus pentachloride / toluene
View Scheme
参考文献
Christensen, Mette K.; Erichsen, Kamille D.; Olesen, Uffe H.; Tjornelund, Jette; Fristrup, Peter; Thougaard, Annemette; Nielsen, Soren Jensby; Sehested, Maxwell; Jensen, Peter B.; Loza, Einars; Kalvinsh, Ivars; Garten, Antje; Kiess, Wieland; Bjoerkling, Fredrik
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9071 - 9088
反应条件
1: With sodium thiosulfate in methanol; water
24 h; Reflux;
2: With iodine in methanol; water
4 h; Reflux;
参考文献
Majouga; Romashkina; Kashaev; Beloglazkina; Moiseeva; Zyk
Russian Chemical Bulletin, 2011 , vol. 60, # 2 p. 261 - 268
参考文献
TOPOTARGET A/S
Patent: WO2009/86835 A1, 2009 ;
Location in patent: Page/Page column 98-99 ;
WO 2009/086835 A1
反应条件
1: 76 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 93 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 17 percent / aq. acetic acid
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 76 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 93 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 52 percent / CHCl3 / 2 h / Heating
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 76 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 93 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 79 percent / CHCl3
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 76 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 93 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 59 percent / triethylamine / benzene
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: 76 percent / tetra-n-butylammonium bromide, potassium hydroxyde / benzene / 6 h / Ambient temperature
2: 93 percent / 1.) 100percent hydrazine hydrate; 2.) aq. 10percent hydrochloric / ethanol / 1.) reflux, 5 h; 2.) pH=4.0, reflux, 2 h
3: 30 percent / triethylamine / benzene
View Scheme
参考文献
Yamada; Tsukamoto; Shimamura; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 3 p. 209 - 214
反应条件
1: ethanol / 4 h / Heating
2: hydrazine
View Scheme
参考文献
Holland, Herbert L.; Brown, Frances M.; Larsen, Brett G.; Zabic, Mirjana
Tetrahedron: Asymmetry, 1995 , vol. 6, # 7 p. 1569 - 1574
反应条件
1: ethanol / 4 h / Heating
2: hydrazine
View Scheme
参考文献
Tolstikova, O. V.; Tolstikov, A. G.; Shmakov, V. S.; Galkin, E. G.; Abdrakhmanov, I. B.; Aripova, S. F.
Chemistry of Natural Compounds, 1988 , vol. 24, # 1 p. 66 - 70
Khimiya Prirodnykh Soedinenii, 1988 , vol. 24, # 1 p. 76 - 82
