N-(4-乙酰基苯基)-2,2,2-三氟乙酰胺合成路线 （共 5 条）
反应条件
potassium phosphate; N-methyl-2-(methylamino)ethylamine; copper(l) iodide in N,N-dimethyl-formamide
T=45°C;
参考文献
Tao, Chuan-Zhou; Li, Juan; Fu, Yao; Liu, Lei; Guo, Qing-Xiang
Tetrahedron Letters, 2008 , vol. 49, # 1 p. 70 - 75
反应条件
potassium carbonate; N-methyl-2-(methylamino)ethylamine; copper(l) iodide in 1,4-dioxane
T=75°C;
参考文献
Tao, Chuan-Zhou; Li, Juan; Fu, Yao; Liu, Lei; Guo, Qing-Xiang
Tetrahedron Letters, 2008 , vol. 49, # 1 p. 70 - 75
反应条件
lithium perchlorate; gallium trifluoromethanesulfonate in nitromethane
T=50°C; Friedel-Crafts acylation; 24 h;
参考文献
Kobayashi, Shu; Komoto, Ichiro; Matsuo, Jun-Ichi
Advanced Synthesis and Catalysis, 2001 , vol. 343, # 1 p. 71 - 74
反应条件
triethylamine in dichloromethane
T=10°C;
参考文献
Prezelj, Andrej; Pecar
Pharmazie, 2002 , vol. 57, # 1 p. 70 - 71
反应条件
1: 74 percent / Br2 / CHCl3 / 0.75 h / Heating
2: 0.08 h
3: NaBH4 / propan-2-ol / 20 °C
4: 8.0 g / aq. NaOH / propan-2-ol / 2 h / pH 12 / Heating
View Scheme
参考文献
Prezelj, Andrej; Pecar
Pharmazie, 2002 , vol. 57, # 1 p. 70 - 71
