in ethanol T=80°C; 2 h;

1: 87 percent / toluene-4-sulfonic acid / 24 h / 20 °C 2: 76 percent / Bu4NF / acetonitrile / 48 h / Heating 3: 94 percent / H2 / PtO2 / ethanol / 24 h / 20 °C 4: 79 percent / CF3COOH / methanol / 0.5 h / 20 °C 5: 80 percent / pyridine / 144 h / -28 °C 6: 90 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 7: 80 percent / pyridine / 48 h / 20 °C 8: 66 percent / dimethylformamide / 24 h / 100 °C 9: 0.7 g / trifluoroacetic acid; aq. HCl / 24 h / 4 °C 10: NaBH4 / methanol / 2 h / 20 °C 11: 84 percent / imidazole; Ph3P; iodine / toluene / 3 h / Heating 12: 83 percent / K2CO3 / methanol; tetrahydrofuran / 1.5 h / 20 °C 13: 93 percent / ethanol / 3 h / 80 °C View Scheme

1: 94 percent / H2 / PtO2 / ethanol / 24 h / 20 °C 2: 79 percent / CF3COOH / methanol / 0.5 h / 20 °C 3: 80 percent / pyridine / 144 h / -28 °C 4: 90 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 5: 80 percent / pyridine / 48 h / 20 °C 6: 66 percent / dimethylformamide / 24 h / 100 °C 7: 0.7 g / trifluoroacetic acid; aq. HCl / 24 h / 4 °C 8: NaBH4 / methanol / 2 h / 20 °C 9: 84 percent / imidazole; Ph3P; iodine / toluene / 3 h / Heating 10: 83 percent / K2CO3 / methanol; tetrahydrofuran / 1.5 h / 20 °C 11: 93 percent / ethanol / 3 h / 80 °C View Scheme

1: 76 percent / Bu4NF / acetonitrile / 48 h / Heating 2: 94 percent / H2 / PtO2 / ethanol / 24 h / 20 °C 3: 79 percent / CF3COOH / methanol / 0.5 h / 20 °C 4: 80 percent / pyridine / 144 h / -28 °C 5: 90 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 6: 80 percent / pyridine / 48 h / 20 °C 7: 66 percent / dimethylformamide / 24 h / 100 °C 8: 0.7 g / trifluoroacetic acid; aq. HCl / 24 h / 4 °C 9: NaBH4 / methanol / 2 h / 20 °C 10: 84 percent / imidazole; Ph3P; iodine / toluene / 3 h / Heating 11: 83 percent / K2CO3 / methanol; tetrahydrofuran / 1.5 h / 20 °C 12: 93 percent / ethanol / 3 h / 80 °C View Scheme

1.1: 83 percent / pyridine / 16 h / 70 °C 2.1: 96 percent / H2 / Pd on CaCO3 / tetrahydrofuran / 1500.12 Torr 3.1: LiHMDS / -78 °C 3.2: MoOPH / 0.5 h / -25 °C 4.1: 85 percent / pyridine / 0 - 20 °C 5.1: tetrahydrofuran; toluene; pyridine / -40 °C 6.1: H2 / Pd on CaCO3 / tetrahydrofuran / 1500.12 Torr 7.1: K2CO3 / methanol 8.1: DEAD; PPh3 / tetrahydrofuran / 0 °C 9.1: aq. K2CO3 / methanol 10.1: 70 percent / NaOAc / 60 °C 11.1: FeCl3*6H2O / CH2Cl2 / 0.33 h / 20 °C 12.1: pyridine / -20 °C 13.1: NaI / butan-2-one / 80 °C 14.1: 72 percent / aq. K2CO3 / methanol 15.1: 92 percent / ethanol / Heating View Scheme

1.1: 96 percent / H2 / Pd on CaCO3 / tetrahydrofuran / 1500.12 Torr 2.1: LiHMDS / -78 °C 2.2: MoOPH / 0.5 h / -25 °C 3.1: 85 percent / pyridine / 0 - 20 °C 4.1: tetrahydrofuran; toluene; pyridine / -40 °C 5.1: H2 / Pd on CaCO3 / tetrahydrofuran / 1500.12 Torr 6.1: K2CO3 / methanol 7.1: DEAD; PPh3 / tetrahydrofuran / 0 °C 8.1: aq. K2CO3 / methanol 9.1: 70 percent / NaOAc / 60 °C 10.1: FeCl3*6H2O / CH2Cl2 / 0.33 h / 20 °C 11.1: pyridine / -20 °C 12.1: NaI / butan-2-one / 80 °C 13.1: 72 percent / aq. K2CO3 / methanol 14.1: 92 percent / ethanol / Heating View Scheme

1.1: LiHMDS / -78 °C 1.2: MoOPH / 0.5 h / -25 °C 2.1: 85 percent / pyridine / 0 - 20 °C 3.1: tetrahydrofuran; toluene; pyridine / -40 °C 4.1: H2 / Pd on CaCO3 / tetrahydrofuran / 1500.12 Torr 5.1: K2CO3 / methanol 6.1: DEAD; PPh3 / tetrahydrofuran / 0 °C 7.1: aq. K2CO3 / methanol 8.1: 70 percent / NaOAc / 60 °C 9.1: FeCl3*6H2O / CH2Cl2 / 0.33 h / 20 °C 10.1: pyridine / -20 °C 11.1: NaI / butan-2-one / 80 °C 12.1: 72 percent / aq. K2CO3 / methanol 13.1: 92 percent / ethanol / Heating View Scheme

1: 86 percent / toluene-4-sulfonic acid / dimethylformamide / 24 h / 70 °C 2: 86 percent / Bu4NF / acetonitrile / 24 h / Heating 3: H2 / Pd/C / ethanol / 4 h / 20 °C 4: 0.45 percent / H2; glacial acetic acid / Pd/C / ethanol / 12 h / 20 °C 5: 80 percent / pyridine / 144 h / -28 °C 6: 90 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 7: 80 percent / pyridine / 48 h / 20 °C 8: 66 percent / dimethylformamide / 24 h / 100 °C 9: 0.7 g / trifluoroacetic acid; aq. HCl / 24 h / 4 °C 10: NaBH4 / methanol / 2 h / 20 °C 11: 84 percent / imidazole; Ph3P; iodine / toluene / 3 h / Heating 12: 83 percent / K2CO3 / methanol; tetrahydrofuran / 1.5 h / 20 °C 13: 93 percent / ethanol / 3 h / 80 °C View Scheme

1: 86 percent / pyridine / 0 - 20 °C 2: tetrahydrofuran; toluene; pyridine / -40 °C 3: H2 / Raney Ni / tetrahydrofuran / 1500.12 Torr 4: 70 percent / NaOAc / 60 °C 5: FeCl3*6H2O / CH2Cl2 / 0.33 h / 20 °C 6: pyridine / -20 °C 7: NaI / butan-2-one / 80 °C 8: 72 percent / aq. K2CO3 / methanol 9: 92 percent / ethanol / Heating View Scheme

1: tetrahydrofuran; toluene; pyridine / -40 °C 2: H2 / Raney Ni / tetrahydrofuran / 1500.12 Torr 3: 70 percent / NaOAc / 60 °C 4: FeCl3*6H2O / CH2Cl2 / 0.33 h / 20 °C 5: pyridine / -20 °C 6: NaI / butan-2-one / 80 °C 7: 72 percent / aq. K2CO3 / methanol 8: 92 percent / ethanol / Heating View Scheme