(+)-蕈毒碱碘化物合成路线

(+)-蕈毒碱碘化物合成路线（共 57 条）

129064-92-2

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24570-49-8(+)-蕈毒碱碘化物

反应条件

1: 83 percent / K2CO3 / methanol; tetrahydrofuran / 1.5 h / 20 °C 2: 93 percent / ethanol / 3 h / 80 °C View Scheme

参考文献

Tetrahedron, , vol. 56, # 32 p. 5929 - 5940

300555-13-9

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24570-49-8(+)-蕈毒碱碘化物

反应条件

1: H2 / Pd/C / ethanol / 4 h / 20 °C 2: 0.45 percent / H2; glacial acetic acid / Pd/C / ethanol / 12 h / 20 °C 3: 80 percent / pyridine / 144 h / -28 °C 4: 90 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 5: 80 percent / pyridine / 48 h / 20 °C 6: 66 percent / dimethylformamide / 24 h / 100 °C 7: 0.7 g / trifluoroacetic acid; aq. HCl / 24 h / 4 °C 8: NaBH4 / methanol / 2 h / 20 °C 9: 84 percent / imidazole; Ph3P; iodine / toluene / 3 h / Heating 10: 83 percent / K2CO3 / methanol; tetrahydrofuran / 1.5 h / 20 °C 11: 93 percent / ethanol / 3 h / 80 °C View Scheme

参考文献

Tetrahedron, , vol. 56, # 32 p. 5929 - 5940

300555-14-0

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24570-49-8(+)-蕈毒碱碘化物

反应条件

1: 0.45 percent / H2; glacial acetic acid / Pd/C / ethanol / 12 h / 20 °C 2: 80 percent / pyridine / 144 h / -28 °C 3: 90 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 4: 80 percent / pyridine / 48 h / 20 °C 5: 66 percent / dimethylformamide / 24 h / 100 °C 6: 0.7 g / trifluoroacetic acid; aq. HCl / 24 h / 4 °C 7: NaBH4 / methanol / 2 h / 20 °C 8: 84 percent / imidazole; Ph3P; iodine / toluene / 3 h / Heating 9: 83 percent / K2CO3 / methanol; tetrahydrofuran / 1.5 h / 20 °C 10: 93 percent / ethanol / 3 h / 80 °C View Scheme

参考文献

Tetrahedron, , vol. 56, # 32 p. 5929 - 5940

300555-11-7

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24570-49-8(+)-蕈毒碱碘化物

反应条件

1: 67 percent / Bu4NF / acetonitrile / 48 h / Heating 2: H2 / Pd/C / ethanol / 4 h / 20 °C 3: 0.45 percent / H2; glacial acetic acid / Pd/C / ethanol / 12 h / 20 °C 4: 80 percent / pyridine / 144 h / -28 °C 5: 90 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 6: 80 percent / pyridine / 48 h / 20 °C 7: 66 percent / dimethylformamide / 24 h / 100 °C 8: 0.7 g / trifluoroacetic acid; aq. HCl / 24 h / 4 °C 9: NaBH4 / methanol / 2 h / 20 °C 10: 84 percent / imidazole; Ph3P; iodine / toluene / 3 h / Heating 11: 83 percent / K2CO3 / methanol; tetrahydrofuran / 1.5 h / 20 °C 12: 93 percent / ethanol / 3 h / 80 °C View Scheme

参考文献

Tetrahedron, , vol. 56, # 32 p. 5929 - 5940

208394-50-7

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24570-49-8(+)-蕈毒碱碘化物

反应条件

1: 82 percent / Bu4NF / acetonitrile / 48 h / Heating 2: 94 percent / H2 / PtO2 / ethanol / 24 h / 20 °C 3: 79 percent / CF3COOH / methanol / 0.5 h / 20 °C 4: 80 percent / pyridine / 144 h / -28 °C 5: 90 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 6: 80 percent / pyridine / 48 h / 20 °C 7: 66 percent / dimethylformamide / 24 h / 100 °C 8: 0.7 g / trifluoroacetic acid; aq. HCl / 24 h / 4 °C 9: NaBH4 / methanol / 2 h / 20 °C 10: 84 percent / imidazole; Ph3P; iodine / toluene / 3 h / Heating 11: 83 percent / K2CO3 / methanol; tetrahydrofuran / 1.5 h / 20 °C 12: 93 percent / ethanol / 3 h / 80 °C View Scheme

参考文献

Tetrahedron, , vol. 56, # 32 p. 5929 - 5940

300555-12-8

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24570-49-8(+)-蕈毒碱碘化物

反应条件

1: 86 percent / Bu4NF / acetonitrile / 24 h / Heating 2: H2 / Pd/C / ethanol / 4 h / 20 °C 3: 0.45 percent / H2; glacial acetic acid / Pd/C / ethanol / 12 h / 20 °C 4: 80 percent / pyridine / 144 h / -28 °C 5: 90 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 6: 80 percent / pyridine / 48 h / 20 °C 7: 66 percent / dimethylformamide / 24 h / 100 °C 8: 0.7 g / trifluoroacetic acid; aq. HCl / 24 h / 4 °C 9: NaBH4 / methanol / 2 h / 20 °C 10: 84 percent / imidazole; Ph3P; iodine / toluene / 3 h / Heating 11: 83 percent / K2CO3 / methanol; tetrahydrofuran / 1.5 h / 20 °C 12: 93 percent / ethanol / 3 h / 80 °C View Scheme

参考文献

Tetrahedron, , vol. 56, # 32 p. 5929 - 5940

313646-60-5

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24570-49-8(+)-蕈毒碱碘化物

反应条件

1: 85 percent / pyridine / 0 - 20 °C 2: tetrahydrofuran; toluene; pyridine / -40 °C 3: H2 / Pd on CaCO3 / tetrahydrofuran / 1500.12 Torr 4: K2CO3 / methanol 5: DEAD; PPh3 / tetrahydrofuran / 0 °C 6: aq. K2CO3 / methanol 7: 70 percent / NaOAc / 60 °C 8: FeCl3*6H2O / CH2Cl2 / 0.33 h / 20 °C 9: pyridine / -20 °C 10: NaI / butan-2-one / 80 °C 11: 72 percent / aq. K2CO3 / methanol 12: 92 percent / ethanol / Heating View Scheme

参考文献

Tetrahedron Letters, , vol. 41, # 42 p. 8137 - 8140

313646-51-4

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24570-49-8(+)-蕈毒碱碘化物

反应条件

1: tetrahydrofuran; toluene; pyridine / -40 °C 2: H2 / Pd on CaCO3 / tetrahydrofuran / 1500.12 Torr 3: K2CO3 / methanol 4: DEAD; PPh3 / tetrahydrofuran / 0 °C 5: aq. K2CO3 / methanol 6: 70 percent / NaOAc / 60 °C 7: FeCl3*6H2O / CH2Cl2 / 0.33 h / 20 °C 8: pyridine / -20 °C 9: NaI / butan-2-one / 80 °C 10: 72 percent / aq. K2CO3 / methanol 11: 92 percent / ethanol / Heating View Scheme

参考文献

Tetrahedron Letters, , vol. 41, # 42 p. 8137 - 8140

208394-56-3

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24570-49-8(+)-蕈毒碱碘化物

反应条件

1: 80 percent / pyridine / 48 h / 20 °C 2: 66 percent / dimethylformamide / 24 h / 100 °C 3: 0.7 g / trifluoroacetic acid; aq. HCl / 24 h / 4 °C 4: NaBH4 / methanol / 2 h / 20 °C 5: 84 percent / imidazole; Ph3P; iodine / toluene / 3 h / Heating 6: 83 percent / K2CO3 / methanol; tetrahydrofuran / 1.5 h / 20 °C 7: 93 percent / ethanol / 3 h / 80 °C View Scheme

参考文献

Tetrahedron, , vol. 56, # 32 p. 5929 - 5940

208394-54-1

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24570-49-8(+)-蕈毒碱碘化物

反应条件

1: 80 percent / pyridine / 144 h / -28 °C 2: 90 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 3: 80 percent / pyridine / 48 h / 20 °C 4: 66 percent / dimethylformamide / 24 h / 100 °C 5: 0.7 g / trifluoroacetic acid; aq. HCl / 24 h / 4 °C 6: NaBH4 / methanol / 2 h / 20 °C 7: 84 percent / imidazole; Ph3P; iodine / toluene / 3 h / Heating 8: 83 percent / K2CO3 / methanol; tetrahydrofuran / 1.5 h / 20 °C 9: 93 percent / ethanol / 3 h / 80 °C View Scheme

参考文献

Tetrahedron, , vol. 56, # 32 p. 5929 - 5940

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