3-(5-氟-1H-吲哚-3-基)丙胺合成路线 (共 3 条)
反应条件
palladium 10 on activated carbon; hydrogen in ethanol P=3075.31 Torr;
参考文献
UNIVERSITE LIBRE DE BEUXELLES
Patent: US2012/122948 A1, 2012 ;
Location in patent: Page/Page column 7 ;
反应条件
1: 99 percent / CBr4; Ph3P / CH2Cl2 / 2 h 2: 89 percent / NaN3 / dimethylformamide / 18 h / 60 °C 3: 61 percent / H2 / Pd/C / ethanol / 16 h / 2585.74 Torr View Scheme
参考文献
Mewshaw, Richard E.; Zhou, Dahui; Zhou, Ping; Shi, Xiaojie; Hornby, Geoffrey; Spangler, Taylor; Scerni, Rosemary; Smith, Deborah; Schechter, Lee E.; Andree, Terrance H.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3823 - 3842
反应条件
1: 89 percent / NaN3 / dimethylformamide / 18 h / 60 °C 2: 61 percent / H2 / Pd/C / ethanol / 16 h / 2585.74 Torr View Scheme
参考文献
Mewshaw, Richard E.; Zhou, Dahui; Zhou, Ping; Shi, Xiaojie; Hornby, Geoffrey; Spangler, Taylor; Scerni, Rosemary; Smith, Deborah; Schechter, Lee E.; Andree, Terrance H.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3823 - 3842