5-氟-2,3-二氢苯并[b]呋喃合成路线 （共 6 条）
反应条件
hydrogen; acetic acid; palladium on activated charcoal P=2585.74 Torr; 12 h;
参考文献
Wyeth
Patent: EP1147083 B1, 2004 ;
Location in patent: Page 35 ;
EP 1147083 B1
反应条件
1.1: NaH / dimethylformamide / 0 °C 1.2: 80 percent / dimethylformamide / 18 h / 160 - 170 °C 2.1: 45 percent / polyphosphoric acid / benzene / 2.5 h / Heating 3.1: 85 percent / H2; AcOH / Pd/C / 12 h / 2585.74 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 15 p. 3823 - 3842
反应条件
1: 45 percent / polyphosphoric acid / benzene / 2.5 h / Heating 2: 85 percent / H2; AcOH / Pd/C / 12 h / 2585.74 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 15 p. 3823 - 3842
反应条件
1: With hydrogenchloride; tetrafluoroboric acid; sodium nitrite in tetrahydrofuran; water T=-15°C; 2: in anhydrous xylene 1 h; RefluxInert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 18 p. 6681 - 6698
反应条件
1.1: 39 percent / TiCl4 / CH2Cl2 / 0 - 20 °C 2.1: 3-tert-butyl-4-hydroxy-5-methylphenyl sulfide; m-CPBA / CH2Cl2 / 16 h / Heating 2.2: 50 percent / aq. NaOH / ethanol / 3 h / 20 °C View Scheme
参考文献
Mewshaw, Richard E.; Zhou, Dahui; Zhou, Ping; Shi, Xiaojie; Hornby, Geoffrey; Spangler, Taylor; Scerni, Rosemary; Smith, Deborah; Schechter, Lee E.; Andree, Terrance H.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3823 - 3842
反应条件
titanium tetrachloride in dichloromethane T=0 - 20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 15 p. 3823 - 3842
