(E)-3-(4-氯苯基)-2-丙烯-1-醇合成路线 （共 6 条）
反应条件
1: Br2 / CH2Cl2 / 0.33 h / 0 °C 2: NaN3 / dimethylsulfoxide / 24 h / 20 °C 3: aq. NaOH / dimethylsulfoxide / 92 h / 0 °C 4: 7 percent / MnO2 / CHCl3 / 5 h / 20 °C View Scheme
参考文献
Alajarin, Mateo; Orenes, Raul-Angel; Vidal, Angel; Pastor, Aurelia
Synthesis, 2003 , # 1 p. 49 - 52
反应条件
palladium 10 on activated carbon; hydrogen in ethyl acetate T=20°C; 12 h;
参考文献
Sharma, Mukul; Rajesh, U. Chinna; Rawat, Diwan S.
Journal of the Indian Chemical Society, 2013 , vol. 90, # 10 p. 1853 - 1860
反应条件
thionyl chloride in chloroform; benzene
参考文献
Hidaka; Hiroyoshi; Tobishi Yakuhin Kogyo Kabushiki Kaisha
Patent: US5081246 A1, 1992 ;
US 5081246 A
反应条件
1.1: manganese(IV) oxide / hexane; ethyl acetate / 20 °C / |Inert atmosphere 2.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / 0 °C / |Inert atmosphere 2.2: 1 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Preuss, Till; Saak, Wolfgang; Doye, Sven
Chemistry - A European Journal, 2013 , vol. 19, # 12 p. 3833 - 3837
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
T=0 - 20°C; 1.5 h;
参考文献
Louvel, Julien; Carvalho, Joao F.S.; Yu, Zhiyi; Soethoudt, Marjolein; Lenselink, Eelke B.; Klaasse, Elisabeth; Brussee, Johannes; Ijzerman, Adriaan P.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9427 - 9440
反应条件
1: 97 percent / pyridine / CH2Cl2 / 18 h / Heating
2: <W(CO)3(η6-C7H8)>, 2-2'-bipyridine / tetrahydrofuran / 18 h / 60 °C
View Scheme
参考文献
Lehmann, Juerg; Lloyd-Jones, Guy C.
Tetrahedron, 1995 , vol. 51, # 32 p. 8863 - 8874
